Aortic pulse wave velocity is associated with the presence and quantity of coronary artery calcium

A community-based study

Iftikhar Jan Kullo, Lawrence F. Bielak, Stephen T Turner, Patrick F. Sheedy, Patricia A. Peyser

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

We investigated the relationship of aortic pulse wave velocity (aPWV), a measure of central arterial stiffness, with the presence and quantity of coronary artery calcium (CAC) in a community-based sample of adults without prior history of heart attack or stroke (n=401, mean age 59.8 years, 53% men). ECG-gated waveforms of the right carotid and right femoral artery were obtained by applanation tonometry, and aPWV was calculated using established methods. CAC was measured noninvasively by electron beam computed tomography, and CAC score was calculated. aPWV was significantly correlated with log(CAC +1; r=0.41; P<0.0001) and pulse pressure (r=0.47; P<0.0001). Multivariable logistic and linear regression models were used to identify independent predictors of the presence and quantity of CAC, respectively. In multivariable logistic regression analyses, aPWV was associated with the presence of CAC (P=0.011) after adjustment for age, male sex, total cholesterol, high-density lipoprotein cholesterol, diabetes, history of smoking, systolic blood pressure, body mass index, and use of hypertension and statin medications. In multivariable linear regression analyses, aPWV was significantly associated with log(CAC +1) after adjustment for the covariates enumerated above (P<0.0001). aPWV remained significantly associated with both the presence and quantity of CAC even after the additional adjustment for diastolic blood pressure. We conclude that aPWV is related to subclinical coronary atherosclerosis independent of conventional risk factors (including indices of blood pressure) and may be a biomarker of cardiovascular risk in asymptomatic individuals.

Original languageEnglish (US)
Pages (from-to)174-179
Number of pages6
JournalHypertension
Volume47
Issue number2
DOIs
StatePublished - Feb 2006

Fingerprint

Pulse Wave Analysis
Coronary Vessels
Calcium
Blood Pressure
Linear Models
Logistic Models
Regression Analysis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Vascular Stiffness
X Ray Computed Tomography
Manometry
Femoral Artery
HDL Cholesterol
Coronary Artery Disease
Electrocardiography
Body Mass Index
Biomarkers
Smoking
Stroke
Myocardial Infarction

Keywords

  • Blood pressure
  • Calcium
  • Epidemiology
  • Imaging
  • Risk factors

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Aortic pulse wave velocity is associated with the presence and quantity of coronary artery calcium : A community-based study. / Kullo, Iftikhar Jan; Bielak, Lawrence F.; Turner, Stephen T; Sheedy, Patrick F.; Peyser, Patricia A.

In: Hypertension, Vol. 47, No. 2, 02.2006, p. 174-179.

Research output: Contribution to journalArticle

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