@article{51c2b15e462d4d1689dba0cb4cb4a1a5,
title = "Aortic hemodynamics and white matter hyperintensities in normotensive postmenopausal women",
abstract = "Hypertension is associated with development of white matter hyperintensities (WMH) in the brain, which are risk factors for mild cognitive impairment. Hormonal shifts at menopause alter vascular function putting women at risk for both hypertension and WMH. Elevations in aortic hemodynamics precede the appearance of clinically defined hypertension but the relationship of aortic hemodynamics to development of WMH in women is not known. Therefore, this study aimed to characterize aortic hemodynamics in relationship to WMH in postmenopausal women. Aortic systolic and diastolic blood pressure (BP), aortic augmentation index (Alx) and aortic round trip travel time (Aortic TR) by tonometry were examined in 53 postmenopausal women (age 60 ± 2 years). WMH was calculated from fluid-attenuated inversion recovery MRI using a semi-automated segmentation algorithm. WMH as a fraction of total white matter volume positively associated with aortic systolic BP (regression coefficient = 0.018; p = 0.04) after adjusting for age. In addition, WMH fraction was positively associated with AIx (0.025; p = 0.04), and inversely associated with Aortic TR (−0.015; p = 0.04) after adjusting for age. Our results suggest that assessing aortic hemodynamics may identify individuals at risk for accelerated development of WMH and guide early treatment to reduce WMH burden and cognitive impairment in the future.",
keywords = "Blood pressure, Cerebrovascular disease, Cognitive aging, MRI, Stroke prevention",
author = "Barnes, {Jill N.} and Harvey, {Ron{\'e}e E.} and Zuk, {Samantha M.} and Lundt, {Emily S.} and Lesnick, {Timothy G.} and Gunter, {Jeffrey L.} and Senjem, {Matthew L.} and Shuster, {Lynne T.} and Miller, {Virginia M.} and Jack, {Clifford R.} and Joyner, {Michael J.} and Kejal Kantarci",
note = "Funding Information: This work was provided by National Institute of Health grants P50 AG044170 (LTS, VMM, MJJ, and KK) HL118154 (JNB), HL83947 (MJJ). Support for laboratory tests was provided, in part, by UL1 TR000135 (National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH), the Department of Surgery, Mayo Clinic and the Mayo Clinic Foundation. Funding Information: Dr. Barnes is funded by NIH HL118154. Ms. Harvey, Ms. Zuk, Ms. Lundt, Mr. Lesnick, Dr. Gunter, Mr. Senjem do not report any disclosures. Dr. Shuster is funded by the NIH P50 AG44170. Dr. Miller is funded by the NIH P50 AG44170. Dr. Jack has provided consulting services for Eli Lilly Co. He receives research funding from the National Institutes of Health ((R01 AG011378, U01 HL096917, U01 AG024904, RO1 AG041851, R01 AG037551, R01 AG043392, U01 AG006786)) and the Alexander Family Alzheimer{\textquoteright}s Disease Research Professorship of the Mayo Foundation. Dr. Joyner is funded by NIH HL83947. Dr. Kantarci serves on the data safety monitoring board for Pfizer Inc., Takeda Global Research & Development Center, Inc.; and she is funded by the NIH [R01AG040042 (PI), R21 NS066147 (PI), Mayo Clinic Alzheimer{\textquoteright}s Disease Research Center/Project 1 P50 AG16574/P1 (PI), P50 AG44170/Project 2 (PI) and R01 AG11378 (Co-I)]. Publisher Copyright: {\textcopyright} 2017, The Author(s).",
year = "2017",
month = may,
day = "1",
doi = "10.1007/s00415-017-8476-1",
language = "English (US)",
volume = "264",
pages = "938--945",
journal = "Deutsche Zeitschrift fur Nervenheilkunde",
issn = "0340-5354",
publisher = "D. Steinkopff-Verlag",
number = "5",
}