Aortic Augmentation Index Is Inversely Associated With Cardiorespiratory Fitness in Men Without Known Coronary Heart Disease

Josepha Binder, Kent R Bailey, James B. Seward, Ray W. Squires, Takamu Kunihiro, Donald D. Hensrud, Iftikhar Jan Kullo

Research output: Contribution to journalArticle

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Abstract

Background: We investigated whether the aortic augmentation index (AIx), a measure of arterial wave reflection and stiffness, is associated with cardiorespiratory fitness in men without known coronary heart disease (CHD). Methods: Asymptomatic men (n = 201, mean age 51 ± 9.2 years) referred for a screening exercise electrocardiogram (ECG) underwent applanation tonometry to obtain radial artery pulse waveforms, and an ascending aortic pressure waveform was derived by a transfer function. The AIx is the difference between the first and second systolic peak of the ascending aortic pressure waveform, expressed as a percentage of the pulse pressure. Cardiorespiratory fitness was assessed by maximal oxygen consumption (VO 2 max mL/min/kg) during a symptom-limited graded exercise test. Multivariable regression analyses were used to identify significant independent determinants of AIx and of VO 2 max. Results: Diabetes was present in 2.5% of subjects, 34.8% had history of smoking, and 29% were hypertensive. Mean (± SD) AIx was 19.9% ± 9.0% and mean VO 2 max was 33.9 ± 6.4 mL/min/kg. In a multivariable linear regression model, AIx was positively associated with age, hypertension, and history of smoking and inversely with heart rate, height, and body mass index (BMI). The VO 2 max was significantly inversely related to AIx after adjustment for age, heart rate, height, and BMI (r = -0.22, P = .002), after further adjustment for CHD risk factors (total cholesterol, HDL-cholesterol, history of smoking, diabetes, hypertension) (P = .006), and after additional adjustment for behavioral factors (physical activity score, alcohol intake, and percent body fat) (P = .022). Conclusions: These findings indicate that AIx, a measure of arterial wave reflection and stiffness, is inversely associated with cardiorespiratory fitness in men without CHD.

Original languageEnglish (US)
Pages (from-to)1019-1024
Number of pages6
JournalAmerican Journal of Hypertension
Volume19
Issue number10
DOIs
StatePublished - Oct 2006

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Coronary Disease
Smoking
Linear Models
Arterial Pressure
Body Mass Index
Heart Rate
Exercise
Hypertension
Radial Artery
Manometry
Exercise Test
Oxygen Consumption
HDL Cholesterol
Pulse
Adipose Tissue
Electrocardiography
Cholesterol
Regression Analysis
Alcohols
Blood Pressure

Keywords

  • Aortic augmentation index fitness
  • arterial stiffness
  • cardiorespiratory fitness
  • wave reflection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Aortic Augmentation Index Is Inversely Associated With Cardiorespiratory Fitness in Men Without Known Coronary Heart Disease. / Binder, Josepha; Bailey, Kent R; Seward, James B.; Squires, Ray W.; Kunihiro, Takamu; Hensrud, Donald D.; Kullo, Iftikhar Jan.

In: American Journal of Hypertension, Vol. 19, No. 10, 10.2006, p. 1019-1024.

Research output: Contribution to journalArticle

Binder, Josepha ; Bailey, Kent R ; Seward, James B. ; Squires, Ray W. ; Kunihiro, Takamu ; Hensrud, Donald D. ; Kullo, Iftikhar Jan. / Aortic Augmentation Index Is Inversely Associated With Cardiorespiratory Fitness in Men Without Known Coronary Heart Disease. In: American Journal of Hypertension. 2006 ; Vol. 19, No. 10. pp. 1019-1024.
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AU - Kunihiro, Takamu

AU - Hensrud, Donald D.

AU - Kullo, Iftikhar Jan

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KW - wave reflection

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