Antinuclear Antibody Staining Only Centrioles in a Patient with Scleroderma

To the Editor: In their letter in the September 17 issue McCarty et al. reported a pattern of staining localized to the mitotic-spindle apparatus.¹ We would like to report the observation of a unique anticentriolar antibody present in a patient with progressive systemic sclerosis. The patient had sclerodactyly, proximal edematous skin changes, and Raynaud's phenomenon. She did not have the carpal-tunnel syndrome, which was a prominent feature in the patients described by McCarty et al. She was not taking alkaloids or colchicine. Her serum cortisol level was normal, and there was no serologic evidence of infectious mononucleosis. The fluorescence staining.