TY - JOUR
T1 - Antihypertensive efficacy of lisinopril ambulatory blood pressure monitoring
AU - Zachariah, Prince K.
AU - Sheps, Sheldon G.
AU - Schwartz, Gary L.
AU - Schirger, Alexander
AU - Ilstrup, Duane M.
AU - Long, Cynthia R.
AU - Carlson, Christopher A.
PY - 1988/7
Y1 - 1988/7
N2 - Noninvasive automatic ambulatory blood pressure monitoring during 24 hours in eight patients with moderate hypertension was used to determine the blood pressure response to lisinopril, an angiotensin-converting enzyme inhibitor. Office, 24-hour ambulatory, awake ambulatory, and sleep ambulatory diastolic blood pressures were decreased from 108 ± 3, 98 ± 8, 101 ± 7, and 87 ± 24 mm Hg, respectively, at baseline to 83 ±4 (P < 0.0001), 82 ±7 (P < 0.0001), 84 ±7 (P < 0.0001), and 73 ±9 mm Hg (P < 0.005), respectively, after 20 weeks of lisinopril treatment (dose range, 40 to 80 mg once daily). The diastolic blood pressure loads (percentages of ambulatory diastolic blood pressures more than 90 mm Hg) during 24 hours and during awake hours were 74% ± 29% and 83% ± 25%, respectively, at baseline and 24% ± 19% (P < 0.0001) and 29% ± 22% (P < 0.0001), respectively, during treatment. Heart rate was not altered by lisinopril. In conclusion, lisinopril is an effective antihypertensive agent for the treatment of moderate hypertension, and ambulatory blood pressures and diastolic blood pressure loads are useful for evaluating therapy for hypertension. Am J Hypertens 1988; 1:274S-279S.
AB - Noninvasive automatic ambulatory blood pressure monitoring during 24 hours in eight patients with moderate hypertension was used to determine the blood pressure response to lisinopril, an angiotensin-converting enzyme inhibitor. Office, 24-hour ambulatory, awake ambulatory, and sleep ambulatory diastolic blood pressures were decreased from 108 ± 3, 98 ± 8, 101 ± 7, and 87 ± 24 mm Hg, respectively, at baseline to 83 ±4 (P < 0.0001), 82 ±7 (P < 0.0001), 84 ±7 (P < 0.0001), and 73 ±9 mm Hg (P < 0.005), respectively, after 20 weeks of lisinopril treatment (dose range, 40 to 80 mg once daily). The diastolic blood pressure loads (percentages of ambulatory diastolic blood pressures more than 90 mm Hg) during 24 hours and during awake hours were 74% ± 29% and 83% ± 25%, respectively, at baseline and 24% ± 19% (P < 0.0001) and 29% ± 22% (P < 0.0001), respectively, during treatment. Heart rate was not altered by lisinopril. In conclusion, lisinopril is an effective antihypertensive agent for the treatment of moderate hypertension, and ambulatory blood pressures and diastolic blood pressure loads are useful for evaluating therapy for hypertension. Am J Hypertens 1988; 1:274S-279S.
KW - Ambulatory blood pressure monitoring
KW - Antihypertensive agent
KW - Lisinopril
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U2 - 10.1093/ajh/1.3.274S
DO - 10.1093/ajh/1.3.274S
M3 - Article
C2 - 2843199
AN - SCOPUS:0023809575
SN - 0895-7061
VL - 1
SP - 274S-279S
JO - American journal of hypertension
JF - American journal of hypertension
IS - 3
ER -