Antigenic alterations in autoimmune thyroid diseases. Observations and hypotheses

M. R. Wick, Mark D Sawyer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In order to further define the pathobiologic changes that occur in Hashimoto's thyroiditis (HT) and Graves' disease (GD), 47 cases of these conditions and six of nodular thyroid hyperplasia were studied. Antibodies to cytokeratin, vimentin, LN-2 (a B-lymphocyte marker), UCHL-1 (a T-lymphocyte marker), and HLA-DR and biotinylated Helix pomatia (Roman snail) lectin, were applied to paraffin sections using the avidin-biotin-peroxidase complex method. Cytokeratin was not expressed in resting epithelium or nodular hyperplasia, but was strongly displayed by injured (HT) or diffusely hyperplastic (GD) glandular tissue. Vimentin was present throughout the cytoplasm of proliferating thyrocytes but was limited to basal portions of resting cells and those of nodular hyperplasia. HLA-DR was observed in injured and hyperplastic thyroid tissue, as was N-acetyl-α-D-galactosamine, the target of H pomatia lectin. UCHL-1-labeled infiltrating lymphocytes were observed in both HT and GD, in areas with minimal epithelial changes, while LN-2 was observed only in association with well-formed lymphoid follicles. These findings suggest that T cells are implicated in the mechanism of both conditions, but that inflammation is not the initiating event for HT and GD; and that a 'switch' in intermediate filament synthesis accompanies HLA-DR and N-acetyl-α-D-galactosamine expression by thyroid epithelium. Since current theories implicate intermediate filaments as intracellular mediators, we hypothesize that certain cytokeratins may be associated with gene activity governing the expression of class II histocompatibility antigens and other membrane glycoproteins in HT and GD.

Original languageEnglish (US)
Pages (from-to)77-81
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume113
Issue number1
StatePublished - 1989
Externally publishedYes

Fingerprint

Hashimoto Disease
Graves Disease
Thyroid Diseases
Autoimmune Diseases
HLA-DR Antigens
Keratins
Hyperplasia
Acetylgalactosamine
Thyroid Gland
Intermediate Filaments
Vimentin
Lectins
Epithelium
T-Lymphocytes
Avidin
Histocompatibility Antigens Class II
Membrane Glycoproteins
Snails
Biotin
Paraffin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Antigenic alterations in autoimmune thyroid diseases. Observations and hypotheses. / Wick, M. R.; Sawyer, Mark D.

In: Archives of Pathology and Laboratory Medicine, Vol. 113, No. 1, 1989, p. 77-81.

Research output: Contribution to journalArticle

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