Antigen specific T cell factor in cell cooperation. Mapping within the I region of the H 2 complex and ability to cooperate across allogeneic barriers

M. J. Taussig, A. J. Munro, R. Campbell, C. S. David, N. A. Staines

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Further mapping of the mouse T cell factor specific for poly (Try, Glu) poly(D) (L)Ala polyLys is reported. It is shown to be a product of the I A subregion of the H 2 complex by the use of antisera either raised specifically against or made specific, by absorption, for different regions of the H 2 complex. The factor cooperates across allogeneic barriers, e.g., when factor produced by one strain is combined with bone marrow cells of other H 2 incompatible strains.

Original languageEnglish (US)
Pages (from-to)694-700
Number of pages7
JournalJournal of Experimental Medicine
Issue number3
StatePublished - Dec 1 1975


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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