Antigen-pulsed neutrophils bearing Ia antigens can induce T lymphocyte proliferative response to the syngeneic or semisyngeneic antigen-primed T lymphocytes

K. Okuda, K. Tani, Y. Ishigatsubo, S. Yokota, C. S. David

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Antigen-pulsed neutrophils from mouse peritoneal cavities displayed a remarkable level of lymphocyte proliferative activities to antigen-primed T lymphocytes. Genetic mapping studies demonstrated that compatibility at the I-A, as well as I-E/C, subregions of the major histocompatibility complex (MHC) was essential for effective presentation of the lysozyme antigen. These antigen-presenting activities were remarkably inhibited by anti-Ia sera. Inhibition tests revealed that neutrophil immune-associated (Ia) antigens seem to be essential for antigen presentation during the initial 8 hr. Elimination studies of antigen-pulsed neutrophils with alloantisera plus complement revealed these antigen-presenting neutrophils bearing both I-A and I-E/C gene products on the same cells. These results suggest that Ia-positive neutrophils might play a role in the immune response through antigen presentation.

Original languageEnglish (US)
Pages (from-to)368-372
Number of pages5
JournalTransplantation
Volume30
Issue number5
StatePublished - 1980

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Histocompatibility Antigens Class II
Neutrophils
T-Lymphocytes
Antigen Presentation
Antigens
Peritoneal Cavity
Muramidase
Major Histocompatibility Complex
Immune Sera
Lymphocytes
Genes

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Antigen-pulsed neutrophils bearing Ia antigens can induce T lymphocyte proliferative response to the syngeneic or semisyngeneic antigen-primed T lymphocytes. / Okuda, K.; Tani, K.; Ishigatsubo, Y.; Yokota, S.; David, C. S.

In: Transplantation, Vol. 30, No. 5, 1980, p. 368-372.

Research output: Contribution to journalArticle

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