Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2

M. A. Lynes, L. L. Lanier, G. F. Babcock, P. J. Wettstein, G. Haughton

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Abstract

Two unusual murine lymphomas, designated CH1 and CH2, were produced in the newly developed double congenic strain of mice, B 10 H-2(a)-H-4(b)p/Wts. Both tumors lack the T cell-specific antigen (thy-1), but express cell surface immunoglobulin and the H-2K, H-2D, and Ia specificities determined by the H-2(a) haplotype. Further studies have demonstrated that these tumors represent 'early' B cells in that they express surface IgM (μ heavy and λ light chains), but do not bear surface δ, γ, or α heavy chains. CH1 and CH2 lack surface C 3 receptors and results from assays for Fc receptors have proven variable. A competition radioimmunoassay directed against the gp71 group-specific antigen of Friend leukemia virus has shown that there is a murine leukemia virus associated with these tumors, however, we have been unable to establish a causal relationship between the virus and this malignancy. A comparison of the surface characteristics of the tumors with other mammalian B cell lymphomas is presented.

Original languageEnglish (US)
Pages (from-to)2352-2357
Number of pages6
JournalJournal of Immunology
Volume121
Issue number6
StatePublished - 1978
Externally publishedYes

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B-Cell Lymphoma
Antigens
Neoplasms
Thy-1 Antigens
Friend murine leukemia virus
Congenic Mice
Murine Leukemia Viruses
B-Cell Antigen Receptors
Fc Receptors
Haplotypes
Radioimmunoassay
Immunoglobulin M
Lymphoma
Leukemia
B-Lymphocytes
Viruses
T-Lymphocytes
Light

ASJC Scopus subject areas

  • Immunology

Cite this

Lynes, M. A., Lanier, L. L., Babcock, G. F., Wettstein, P. J., & Haughton, G. (1978). Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2. Journal of Immunology, 121(6), 2352-2357.

Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2. / Lynes, M. A.; Lanier, L. L.; Babcock, G. F.; Wettstein, P. J.; Haughton, G.

In: Journal of Immunology, Vol. 121, No. 6, 1978, p. 2352-2357.

Research output: Contribution to journalArticle

Lynes, MA, Lanier, LL, Babcock, GF, Wettstein, PJ & Haughton, G 1978, 'Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2', Journal of Immunology, vol. 121, no. 6, pp. 2352-2357.
Lynes MA, Lanier LL, Babcock GF, Wettstein PJ, Haughton G. Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2. Journal of Immunology. 1978;121(6):2352-2357.
Lynes, M. A. ; Lanier, L. L. ; Babcock, G. F. ; Wettstein, P. J. ; Haughton, G. / Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2. In: Journal of Immunology. 1978 ; Vol. 121, No. 6. pp. 2352-2357.
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