Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2

M. A. Lynes, L. L. Lanier, G. F. Babcock, P. J. Wettstein, G. Haughton

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28 Scopus citations

Abstract

Two unusual murine lymphomas, designated CH1 and CH2, were produced in the newly developed double congenic strain of mice, B 10 H-2(a)-H-4(b)p/Wts. Both tumors lack the T cell-specific antigen (thy-1), but express cell surface immunoglobulin and the H-2K, H-2D, and Ia specificities determined by the H-2(a) haplotype. Further studies have demonstrated that these tumors represent 'early' B cells in that they express surface IgM (μ heavy and λ light chains), but do not bear surface δ, γ, or α heavy chains. CH1 and CH2 lack surface C 3 receptors and results from assays for Fc receptors have proven variable. A competition radioimmunoassay directed against the gp71 group-specific antigen of Friend leukemia virus has shown that there is a murine leukemia virus associated with these tumors, however, we have been unable to establish a causal relationship between the virus and this malignancy. A comparison of the surface characteristics of the tumors with other mammalian B cell lymphomas is presented.

Original languageEnglish (US)
Pages (from-to)2352-2357
Number of pages6
JournalJournal of Immunology
Volume121
Issue number6
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Lynes, M. A., Lanier, L. L., Babcock, G. F., Wettstein, P. J., & Haughton, G. (1978). Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2. Journal of Immunology, 121(6), 2352-2357.