Antidepressants are weak competitive antagonists of histamine H2 receptors in dissociated brain tissue

Shigenobu Kanba, Elliott Richelson

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Guinea pig hippocampus dissociated by mechanical means into uniform clumps of cells (∼ 100 μm in diameter) contains histamine receptors (H1 and H2) which mediate the formation of cyclic AMP. In this preparation, antidepressants are very potent antagonists of histamine H1 receptors but are weak antagonists of histamine H2 receptors. The latter result is contrary to data derived by others using homogenates of the guinea pig hippocampus and seems to dispel the idea that antidepressants derive their efficacy by blocking histamine H2 receptors in brain.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalEuropean Journal of Pharmacology
Issue number3-4
StatePublished - Oct 28 1983


  • Histamine H receptors Guinea pig hippocampus Antidepressants Antipsychotics Histamine H receptors [H]Trimipramine

ASJC Scopus subject areas

  • Pharmacology


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