Anticipating potential linezolid-SSRI interactions in the general hospital setting: An MAOI in disguise

Christopher L. Sola, J. Michael Bostwick, Dionne A. Hart, Timothy W. Lineberry

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Linezolid, a novel antimicrobial with activity against gram-positive bacteria including pathogens resistant to traditional antimicrobials, also inhibits monoamine oxidase. This latter property can cause potentially lethal adverse interactions with antidepressant medications. Long known to psychiatrists, monoamine oxidase inhibitors (MAOIs) and complications of their use may be unfamiliar to medical and surgical practitioners who may thus unwittingly precipitate a hypertensive crisis or serotonin syndrome. We review the pharmacology of MAOIs and describe 3 clinical situations in which linezolid-selective serotonin inhibitor (SSRI) interactions, actual or potential, figured prominently.

Original languageEnglish (US)
Pages (from-to)330-334
Number of pages5
JournalMayo Clinic proceedings
Volume81
Issue number3
DOIs
StatePublished - Mar 2006

ASJC Scopus subject areas

  • Medicine(all)

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