Anticancer efficiency of curcumin-loaded invertible polymer micellar nanoassemblies

Ivan Hevus, Andriy Voronov, Michael J Yaszemski, Avudaiappan Maran, Ananiy Kohut, Stanislav Voronov

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Recently synthesized amphiphilic invertible polymers (AIPs) are considered as good candidates for micellar delivery of hydrophobic (poorly water-soluble) drugs. Macromolecules of the AIPs self-assemble into invertible micellar assemblies (IMAs) by increasing polymer concentration in solution, and are capable of inverting macromolecular conformation by changing solvent polarity. Being nontoxic against human cells, IMAs are able to solubilize, deliver, and release poorly water-soluble curcumin to treat osteosarcoma cells. The loading into micellar polymer nanoassemblies significantly improves the bioavailability of curcumin in aqueous medium. The mechanism of curcumin release from IMAs depends on AIP chemical structure and might result from macromolecular inversion only, due to changing polarity of the environment. Loaded with curcumin IMAs are stable in aqueous (polar) medium. However, once the drug-loaded assemblies approach cell membrane (less polar), it triggers the macromolecular inversion and drug release due to the enhanced interactions between the membrane and the drug.

Original languageEnglish (US)
Title of host publicationNanostructures for Cancer Therapy
PublisherElsevier Inc.
Pages351-382
Number of pages32
ISBN (Electronic)9780323461504
ISBN (Print)9780323461443
DOIs
StatePublished - Apr 14 2017

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Keywords

  • Amphiphilic invertible polymers
  • Cancer treatment
  • Curcumin delivery
  • Invertible micellar nanoassemblies
  • Smart materials

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hevus, I., Voronov, A., Yaszemski, M. J., Maran, A., Kohut, A., & Voronov, S. (2017). Anticancer efficiency of curcumin-loaded invertible polymer micellar nanoassemblies. In Nanostructures for Cancer Therapy (pp. 351-382). Elsevier Inc.. https://doi.org/10.1016/B978-0-323-46144-3.00014-3