TY - JOUR
T1 - Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells
AU - Celia, Christian
AU - Trapasso, Elena
AU - Locatelli, Marcello
AU - Navarra, Michele
AU - Ventura, Cinzia Anna
AU - Wolfram, Joy
AU - Carafa, Maria
AU - Morittu, Valeria Maria
AU - Britti, Domenico
AU - Di Marzio, Luisa
AU - Paolino, Donatella
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Citrus extracts, particularly bergamot essential oil (BEO) and its fractions, have been found to exhibit anticancer efficacy. However, the poor water solubility, low stability and limited bioavailability have prevented the use of BEO in cancer therapy. To overcome such drawbacks, we formulated BEO liposomes that improved the water solubility of the phytocomponents and increased their anticancer activity in vitro against human SH-SY5Y neuroblastoma cells. The results warrant further investigation of BEO liposomes for in vivo applications.
AB - Citrus extracts, particularly bergamot essential oil (BEO) and its fractions, have been found to exhibit anticancer efficacy. However, the poor water solubility, low stability and limited bioavailability have prevented the use of BEO in cancer therapy. To overcome such drawbacks, we formulated BEO liposomes that improved the water solubility of the phytocomponents and increased their anticancer activity in vitro against human SH-SY5Y neuroblastoma cells. The results warrant further investigation of BEO liposomes for in vivo applications.
KW - Bergamot essential oil (BEO)
KW - Cancer
KW - Citrus extracts
KW - Liposomes
KW - Natural products
KW - SH-SY5Y human neuroblastoma cells
UR - http://www.scopus.com/inward/record.url?scp=84887017025&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887017025&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2013.09.017
DO - 10.1016/j.colsurfb.2013.09.017
M3 - Article
C2 - 24099646
AN - SCOPUS:84887017025
SN - 0927-7765
VL - 112
SP - 548
EP - 553
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
ER -