Antibody to acetylcholine receptor in myasthenia gravis: Prevalence, clinical correlates, and diagnostic value

Jon M. Lindstrom, Marjorie E. Seybold, Vanda A. Lennon, Senga Whittingham, Drake D. Duane

Research output: Contribution to journalArticle

1065 Scopus citations

Abstract

Elevated amounts of antibodies specific for acetylcholine receptors were detected in 87 percent of sera from 71 patients with myasthenia gravis but not in 175 sera from individuals without myasthenia gravis, including those with other neurologic or autoimmune diseases. Antireceptor antibodies were not directed at the acetylcholine binding site of the receptor. Presence or titer of antibody did not appear to correlate with age, sex, steroid therapy, or duration of symptoms. Myasthenia gravis patients with only ocular symptoms had lower antibody titers, while the majority of titers in myasthenia gravis patients with thymoma exceeded the median titer of the myasthenia gravis group as a whole. Assay of antireceptor antibody should prove a useful test in the diagnosis of myasthenia gravis.

Original languageEnglish (US)
Pages (from-to)1054-1059
Number of pages6
JournalNeurology
Volume26
Issue number11
StatePublished - Nov 1976

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ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lindstrom, J. M., Seybold, M. E., Lennon, V. A., Whittingham, S., & Duane, D. D. (1976). Antibody to acetylcholine receptor in myasthenia gravis: Prevalence, clinical correlates, and diagnostic value. Neurology, 26(11), 1054-1059.