Antibiofilm activity of electrical current in a catheter model

Paul Voegele, Jon Badiola, Suzannah M. Schmidt-Malan, Melissa J. Karau, Kerryl E. Greenwood-Quaintance, Jayawant Mandrekar, Robin Patel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Catheter-associated infections are difficult to treat with available antimicrobial agents because of their biofilm etiology. We examined the effect of low-amperage direct electrical current (DC) exposure on established bacterial and fungal biofilms in a novel experimental in vitro catheter model. Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida parapsilosis biofilms were grown on the inside surfaces of polyvinyl chloride (PVC) catheters, after which 0, 100, 200, or 500 μA of DC was delivered via intraluminally placed platinum electrodes. Catheter biofilms and intraluminal fluid were quantitatively cultured after 24 h and 4 days of DC exposure. Time- and dose-dependent biofilm killing was observed with all amperages and durations of DC administration. Twenty-four hours of 500 μA of DC sterilized the intraluminal fluid for all bacterial species studied; no viable bacteria were detected after treatment of S. epidermidis and S. aureus biofilms with 500 μA of DC for 4 days.

Original languageEnglish (US)
Pages (from-to)1476-1480
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Biofilms
Catheters
Staphylococcus epidermidis
Staphylococcus aureus
Catheter-Related Infections
Anti-Infective Agents
Platinum
Candida
Polyvinyl Chloride
Pseudomonas aeruginosa
Electrodes
Escherichia coli
Bacteria

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Voegele, P., Badiola, J., Schmidt-Malan, S. M., Karau, M. J., Greenwood-Quaintance, K. E., Mandrekar, J., & Patel, R. (2016). Antibiofilm activity of electrical current in a catheter model. Antimicrobial Agents and Chemotherapy, 60(3), 1476-1480. https://doi.org/10.1128/AAC.01628-15

Antibiofilm activity of electrical current in a catheter model. / Voegele, Paul; Badiola, Jon; Schmidt-Malan, Suzannah M.; Karau, Melissa J.; Greenwood-Quaintance, Kerryl E.; Mandrekar, Jayawant; Patel, Robin.

In: Antimicrobial Agents and Chemotherapy, Vol. 60, No. 3, 01.03.2016, p. 1476-1480.

Research output: Contribution to journalArticle

Voegele, P, Badiola, J, Schmidt-Malan, SM, Karau, MJ, Greenwood-Quaintance, KE, Mandrekar, J & Patel, R 2016, 'Antibiofilm activity of electrical current in a catheter model', Antimicrobial Agents and Chemotherapy, vol. 60, no. 3, pp. 1476-1480. https://doi.org/10.1128/AAC.01628-15
Voegele P, Badiola J, Schmidt-Malan SM, Karau MJ, Greenwood-Quaintance KE, Mandrekar J et al. Antibiofilm activity of electrical current in a catheter model. Antimicrobial Agents and Chemotherapy. 2016 Mar 1;60(3):1476-1480. https://doi.org/10.1128/AAC.01628-15
Voegele, Paul ; Badiola, Jon ; Schmidt-Malan, Suzannah M. ; Karau, Melissa J. ; Greenwood-Quaintance, Kerryl E. ; Mandrekar, Jayawant ; Patel, Robin. / Antibiofilm activity of electrical current in a catheter model. In: Antimicrobial Agents and Chemotherapy. 2016 ; Vol. 60, No. 3. pp. 1476-1480.
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