TY - JOUR
T1 - Antibacterial activity of reduced iron clay against pathogenic bacteria associated with wound infections
AU - Caflisch, Katherine M.
AU - Schmidt-Malan, Suzannah M.
AU - Mandrekar, Jayawant N.
AU - Karau, Melissa J.
AU - Nicklas, Jonathan P.
AU - Williams, Lynda B.
AU - Patel, Robin
N1 - Publisher Copyright:
© 2018 Elsevier B.V. and International Society of Chemotherapy
PY - 2018/11
Y1 - 2018/11
N2 - Clay is a substance historically utilized by indigenous cultures for the treatment of superficial wound infections. This study evaluated the effects of a recently identified clay – OMT Blue Clay – against staphylococci, streptococci, Enterobacteriaceae and non-fermenting Gram-negative bacilli. The clay and its aqueous leachate were evaluated against the bacteria in biofilm and planktonic states. Time-kill studies were used to assess planktonic activity. Biofilms on medical-grade Teflon discs were treated with a hydrated clay suspension or leachate. For the planktonic studies, clay and leachate exhibited bactericidal activity against all strains tested, with the exception of leachate against Staphylococcus aureus IDRL-6169 and USA300. All strains treated with clay suspension and leachate resulted in statistically significant biofilm population reductions compared with controls, except S. aureus IDRL-6169 and USA300 (P ≤ 0.05). OMT Blue Clay and its aqueous leachate exhibited bactericidal activity against a range of human pathogens in the planktonic and biofilm states.
AB - Clay is a substance historically utilized by indigenous cultures for the treatment of superficial wound infections. This study evaluated the effects of a recently identified clay – OMT Blue Clay – against staphylococci, streptococci, Enterobacteriaceae and non-fermenting Gram-negative bacilli. The clay and its aqueous leachate were evaluated against the bacteria in biofilm and planktonic states. Time-kill studies were used to assess planktonic activity. Biofilms on medical-grade Teflon discs were treated with a hydrated clay suspension or leachate. For the planktonic studies, clay and leachate exhibited bactericidal activity against all strains tested, with the exception of leachate against Staphylococcus aureus IDRL-6169 and USA300. All strains treated with clay suspension and leachate resulted in statistically significant biofilm population reductions compared with controls, except S. aureus IDRL-6169 and USA300 (P ≤ 0.05). OMT Blue Clay and its aqueous leachate exhibited bactericidal activity against a range of human pathogens in the planktonic and biofilm states.
KW - Antibacterial clay
KW - Biofilm
KW - Drug-resistant bacteria
UR - http://www.scopus.com/inward/record.url?scp=85054448893&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054448893&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2018.07.018
DO - 10.1016/j.ijantimicag.2018.07.018
M3 - Article
C2 - 30075292
AN - SCOPUS:85054448893
SN - 0924-8579
VL - 52
SP - 692
EP - 696
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 5
ER -