TY - JOUR
T1 - Antiapoptotic mechanism of HIV protease inhibitors
T2 - Preventing mitochondrial transmembrane potential loss
AU - Phenix, Barbara N.
AU - Lum, Julian J.
AU - Nie, Zehn
AU - Sanchez-Dardon, Jaime
AU - Badley, Andrew D.
PY - 2001/8/15
Y1 - 2001/8/15
N2 - Treatment of cells with the HIV drugs ritonavir, saquinavir, or nelfinavir (Nfv) inhibits apoptosis induced by a variety of stimuli. Because these drugs are protease inhibitors, they have been postulated to inhibit apoptosis by blocking caspase activity. This study shows that Nfv has no effect on caspase activity or on the transcription or synthesis of a variety of apoptosis regulatory molecules. Instead, Nfv inhibits mitochondrial transmembrane potential loss (ΔΨm) and the subsequent release of apoptotic mediators. Consequently, the antiapoptotic effects of Nfv are restricted to apoptotic pathways that involve ΔΨm.
AB - Treatment of cells with the HIV drugs ritonavir, saquinavir, or nelfinavir (Nfv) inhibits apoptosis induced by a variety of stimuli. Because these drugs are protease inhibitors, they have been postulated to inhibit apoptosis by blocking caspase activity. This study shows that Nfv has no effect on caspase activity or on the transcription or synthesis of a variety of apoptosis regulatory molecules. Instead, Nfv inhibits mitochondrial transmembrane potential loss (ΔΨm) and the subsequent release of apoptotic mediators. Consequently, the antiapoptotic effects of Nfv are restricted to apoptotic pathways that involve ΔΨm.
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U2 - 10.1182/blood.V98.4.1078
DO - 10.1182/blood.V98.4.1078
M3 - Article
C2 - 11493454
AN - SCOPUS:0035883068
VL - 98
SP - 1078
EP - 1085
JO - Blood
JF - Blood
SN - 0006-4971
IS - 4
ER -