Antiapoptotic mechanism of HIV protease inhibitors

Preventing mitochondrial transmembrane potential loss

Barbara N. Phenix, Julian J. Lum, Zehn Nie, Jaime Sanchez-Dardon, Andrew David Badley

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Treatment of cells with the HIV drugs ritonavir, saquinavir, or nelfinavir (Nfv) inhibits apoptosis induced by a variety of stimuli. Because these drugs are protease inhibitors, they have been postulated to inhibit apoptosis by blocking caspase activity. This study shows that Nfv has no effect on caspase activity or on the transcription or synthesis of a variety of apoptosis regulatory molecules. Instead, Nfv inhibits mitochondrial transmembrane potential loss (ΔΨm) and the subsequent release of apoptotic mediators. Consequently, the antiapoptotic effects of Nfv are restricted to apoptotic pathways that involve ΔΨm.

Original languageEnglish (US)
Pages (from-to)1078-1085
Number of pages8
JournalBlood
Volume98
Issue number4
DOIs
StatePublished - Aug 15 2001
Externally publishedYes

Fingerprint

Nelfinavir
HIV Protease Inhibitors
Membrane Potentials
Apoptosis
Caspases
Saquinavir
Ritonavir
Transcription
Protease Inhibitors
Pharmaceutical Preparations
Cells
HIV
Molecules

ASJC Scopus subject areas

  • Hematology

Cite this

Antiapoptotic mechanism of HIV protease inhibitors : Preventing mitochondrial transmembrane potential loss. / Phenix, Barbara N.; Lum, Julian J.; Nie, Zehn; Sanchez-Dardon, Jaime; Badley, Andrew David.

In: Blood, Vol. 98, No. 4, 15.08.2001, p. 1078-1085.

Research output: Contribution to journalArticle

Phenix, Barbara N. ; Lum, Julian J. ; Nie, Zehn ; Sanchez-Dardon, Jaime ; Badley, Andrew David. / Antiapoptotic mechanism of HIV protease inhibitors : Preventing mitochondrial transmembrane potential loss. In: Blood. 2001 ; Vol. 98, No. 4. pp. 1078-1085.
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