Abstract
Treatment of cells with the HIV drugs ritonavir, saquinavir, or nelfinavir (Nfv) inhibits apoptosis induced by a variety of stimuli. Because these drugs are protease inhibitors, they have been postulated to inhibit apoptosis by blocking caspase activity. This study shows that Nfv has no effect on caspase activity or on the transcription or synthesis of a variety of apoptosis regulatory molecules. Instead, Nfv inhibits mitochondrial transmembrane potential loss (ΔΨm) and the subsequent release of apoptotic mediators. Consequently, the antiapoptotic effects of Nfv are restricted to apoptotic pathways that involve ΔΨm.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1078-1085 |
| Number of pages | 8 |
| Journal | Blood |
| Volume | 98 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 15 2001 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Hematology
Cite this
Antiapoptotic mechanism of HIV protease inhibitors : Preventing mitochondrial transmembrane potential loss. / Phenix, Barbara N.; Lum, Julian J.; Nie, Zehn; Sanchez-Dardon, Jaime; Badley, Andrew David.
In: Blood, Vol. 98, No. 4, 15.08.2001, p. 1078-1085.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiapoptotic mechanism of HIV protease inhibitors
T2 - Preventing mitochondrial transmembrane potential loss
AU - Phenix, Barbara N.
AU - Lum, Julian J.
AU - Nie, Zehn
AU - Sanchez-Dardon, Jaime
AU - Badley, Andrew David
PY - 2001/8/15
Y1 - 2001/8/15
N2 - Treatment of cells with the HIV drugs ritonavir, saquinavir, or nelfinavir (Nfv) inhibits apoptosis induced by a variety of stimuli. Because these drugs are protease inhibitors, they have been postulated to inhibit apoptosis by blocking caspase activity. This study shows that Nfv has no effect on caspase activity or on the transcription or synthesis of a variety of apoptosis regulatory molecules. Instead, Nfv inhibits mitochondrial transmembrane potential loss (ΔΨm) and the subsequent release of apoptotic mediators. Consequently, the antiapoptotic effects of Nfv are restricted to apoptotic pathways that involve ΔΨm.
AB - Treatment of cells with the HIV drugs ritonavir, saquinavir, or nelfinavir (Nfv) inhibits apoptosis induced by a variety of stimuli. Because these drugs are protease inhibitors, they have been postulated to inhibit apoptosis by blocking caspase activity. This study shows that Nfv has no effect on caspase activity or on the transcription or synthesis of a variety of apoptosis regulatory molecules. Instead, Nfv inhibits mitochondrial transmembrane potential loss (ΔΨm) and the subsequent release of apoptotic mediators. Consequently, the antiapoptotic effects of Nfv are restricted to apoptotic pathways that involve ΔΨm.
UR - http://www.scopus.com/inward/record.url?scp=0035883068&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035883068&partnerID=8YFLogxK
U2 - 10.1182/blood.V98.4.1078
DO - 10.1182/blood.V98.4.1078
M3 - Article
VL - 98
SP - 1078
EP - 1085
JO - Blood
JF - Blood
SN - 0006-4971
IS - 4
ER -