Antiapoptotic mechanism of HIV protease inhibitors: Preventing mitochondrial transmembrane potential loss

Barbara N. Phenix, Julian J. Lum, Zehn Nie, Jaime Sanchez-Dardon, Andrew D. Badley

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

Treatment of cells with the HIV drugs ritonavir, saquinavir, or nelfinavir (Nfv) inhibits apoptosis induced by a variety of stimuli. Because these drugs are protease inhibitors, they have been postulated to inhibit apoptosis by blocking caspase activity. This study shows that Nfv has no effect on caspase activity or on the transcription or synthesis of a variety of apoptosis regulatory molecules. Instead, Nfv inhibits mitochondrial transmembrane potential loss (ΔΨm) and the subsequent release of apoptotic mediators. Consequently, the antiapoptotic effects of Nfv are restricted to apoptotic pathways that involve ΔΨm.

Original languageEnglish (US)
Pages (from-to)1078-1085
Number of pages8
JournalBlood
Volume98
Issue number4
DOIs
StatePublished - Aug 15 2001

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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