Anti-type II collagen antibodies in rheumatoid arthritis. The influence of HLA phenotype

P. H. Wooley, H. S. Luthra, J. D. O'Duffy, T. W. Bunch, S. B. Moore, J. M. Stuart

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Antibodies to native chick and bovine Type II collagen were measured by radio immunoassay, in 83 rheumatoid arthritis (RA) patients and 14 normal controls. Anti-chick Type II collagen and anti-bovine Type II collagen antibodies were found in 48% and 43% of RA patients, respectively. A strong correlation of antibodies to chick and antibodies to bovine collagen was described, suggesting cross-reactivity between different collagen species. There was an association between the presence of anti-native Tpe II collagen antibody and the expression of HLA-DR2. It is suggested that the production of anti-collagen antibody may be under genetic contol in RA, but not associated with the major genetic marker of disease susceptibility, HLA-DR4.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalTissue Antigens
Volume23
Issue number5
StatePublished - 1984

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Collagen Type II
Rheumatoid Arthritis
Phenotype
Collagen
Antibodies
HLA-DR2 Antigen
HLA-DR4 Antigen
Inborn Genetic Diseases
Disease Susceptibility
Radio
Genetic Markers
Immunoassay
Anti-Idiotypic Antibodies

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Wooley, P. H., Luthra, H. S., O'Duffy, J. D., Bunch, T. W., Moore, S. B., & Stuart, J. M. (1984). Anti-type II collagen antibodies in rheumatoid arthritis. The influence of HLA phenotype. Tissue Antigens, 23(5), 263-269.

Anti-type II collagen antibodies in rheumatoid arthritis. The influence of HLA phenotype. / Wooley, P. H.; Luthra, H. S.; O'Duffy, J. D.; Bunch, T. W.; Moore, S. B.; Stuart, J. M.

In: Tissue Antigens, Vol. 23, No. 5, 1984, p. 263-269.

Research output: Contribution to journalArticle

Wooley, PH, Luthra, HS, O'Duffy, JD, Bunch, TW, Moore, SB & Stuart, JM 1984, 'Anti-type II collagen antibodies in rheumatoid arthritis. The influence of HLA phenotype', Tissue Antigens, vol. 23, no. 5, pp. 263-269.
Wooley PH, Luthra HS, O'Duffy JD, Bunch TW, Moore SB, Stuart JM. Anti-type II collagen antibodies in rheumatoid arthritis. The influence of HLA phenotype. Tissue Antigens. 1984;23(5):263-269.
Wooley, P. H. ; Luthra, H. S. ; O'Duffy, J. D. ; Bunch, T. W. ; Moore, S. B. ; Stuart, J. M. / Anti-type II collagen antibodies in rheumatoid arthritis. The influence of HLA phenotype. In: Tissue Antigens. 1984 ; Vol. 23, No. 5. pp. 263-269.
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