Anti-type II collagen antibodies in rheumatoid arthritis. The influence of HLA phenotype

P. H. Wooley, H. S. Luthra, J. D. O'Duffy, T. W. Bunch, S. B. Moore, J. M. Stuart

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Abstract

Antibodies to native chick and bovine Type II collagen were measured by radio immunoassay, in 83 rheumatoid arthritis (RA) patients and 14 normal controls. Anti-chick Type II collagen and anti-bovine Type II collagen antibodies were found in 48% and 43% of RA patients, respectively. A strong correlation of antibodies to chick and antibodies to bovine collagen was described, suggesting cross-reactivity between different collagen species. There was an association between the presence of anti-native Tpe II collagen antibody and the expression of HLA-DR2. It is suggested that the production of anti-collagen antibody may be under genetic contol in RA, but not associated with the major genetic marker of disease susceptibility, HLA-DR4.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalTissue Antigens
Volume23
Issue number5
StatePublished - 1984

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ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Wooley, P. H., Luthra, H. S., O'Duffy, J. D., Bunch, T. W., Moore, S. B., & Stuart, J. M. (1984). Anti-type II collagen antibodies in rheumatoid arthritis. The influence of HLA phenotype. Tissue Antigens, 23(5), 263-269.