TY - JOUR
T1 - Anti-Neutrophil Cytoplasmic Autoantibodies
AU - Specks, Ulrich
AU - Rohrbach, Michael S.
AU - Deremee, Richard A.
AU - Jennette, J. Charles
AU - Falk, Ronald J.
PY - 1988/11/24
Y1 - 1988/11/24
N2 - To the Editor: We commend Drs. Falk and Jennette (June 23 issue)1 for their important observation that at least two types of antibodies against neutrophil components may be present in the serum of patients with various forms of systemic vasculitis. However, on the basis of previous reports2 3 4 5 6 7 8 and our own experience9 with autoantibodies against cytoplasmic components of neutrophils and monocytes (ACPA), also called anti-neutrophil cytoplasmic antibodies by some investigators,5,10 we do not agree with the conclusions drawn by Falk and Jennette. The antibodies described in previous publications2 3 4 5 6 7 8 cause a characteristic staining pattern of fine granular, centrally accentuated immunofluorescence in the.
AB - To the Editor: We commend Drs. Falk and Jennette (June 23 issue)1 for their important observation that at least two types of antibodies against neutrophil components may be present in the serum of patients with various forms of systemic vasculitis. However, on the basis of previous reports2 3 4 5 6 7 8 and our own experience9 with autoantibodies against cytoplasmic components of neutrophils and monocytes (ACPA), also called anti-neutrophil cytoplasmic antibodies by some investigators,5,10 we do not agree with the conclusions drawn by Falk and Jennette. The antibodies described in previous publications2 3 4 5 6 7 8 cause a characteristic staining pattern of fine granular, centrally accentuated immunofluorescence in the.
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U2 - 10.1056/NEJM198811243192114
DO - 10.1056/NEJM198811243192114
M3 - Letter
C2 - 3185657
AN - SCOPUS:0023815570
SN - 0028-4793
VL - 319
SP - 1416
EP - 1417
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 21
ER -