Anti-MuSK myasthenia gravis presenting with purely ocular findings

James B. Caress; Christopher H. Hunt; Sat Dev Batish

doi:10.1001/archneur.62.6.1002

Anti-MuSK myasthenia gravis presenting with purely ocular findings

James B. Caress, Christopher H. Hunt, Sat Dev Batish

Radiology

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Background: Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) have been found in approximately 40% of patients with generalized myasthenia gravis who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weakness of the neck and respiratory muscles, but patients with ocular myasthenia have not been described. Objective: To report a case of ocular myasthenia due to anti-MuSK antibodies. Patient: A young woman with ocular myasthenia and antibodies to MuSK. Results: Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen. Conclusion: Ocular myasthenia gravis is a presentation of the anti-MuSK antibody syndrome.

Original language	English (US)
Pages (from-to)	1002-1003
Number of pages	2
Journal	Archives of neurology
Volume	62
Issue number	6
DOIs	https://doi.org/10.1001/archneur.62.6.1002
State	Published - Jun 2005

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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title = "Anti-MuSK myasthenia gravis presenting with purely ocular findings",

abstract = "Background: Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) have been found in approximately 40% of patients with generalized myasthenia gravis who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weakness of the neck and respiratory muscles, but patients with ocular myasthenia have not been described. Objective: To report a case of ocular myasthenia due to anti-MuSK antibodies. Patient: A young woman with ocular myasthenia and antibodies to MuSK. Results: Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen. Conclusion: Ocular myasthenia gravis is a presentation of the anti-MuSK antibody syndrome.",

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AU - Caress, James B.

AU - Hunt, Christopher H.

AU - Batish, Sat Dev

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N2 - Background: Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) have been found in approximately 40% of patients with generalized myasthenia gravis who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weakness of the neck and respiratory muscles, but patients with ocular myasthenia have not been described. Objective: To report a case of ocular myasthenia due to anti-MuSK antibodies. Patient: A young woman with ocular myasthenia and antibodies to MuSK. Results: Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen. Conclusion: Ocular myasthenia gravis is a presentation of the anti-MuSK antibody syndrome.

AB - Background: Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) have been found in approximately 40% of patients with generalized myasthenia gravis who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weakness of the neck and respiratory muscles, but patients with ocular myasthenia have not been described. Objective: To report a case of ocular myasthenia due to anti-MuSK antibodies. Patient: A young woman with ocular myasthenia and antibodies to MuSK. Results: Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen. Conclusion: Ocular myasthenia gravis is a presentation of the anti-MuSK antibody syndrome.

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Anti-MuSK myasthenia gravis presenting with purely ocular findings

Abstract

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