Anti-MuSK myasthenia gravis presenting with purely ocular findings

James B. Caress, Christopher H. Hunt, Sat Dev Batish

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background: Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) have been found in approximately 40% of patients with generalized myasthenia gravis who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weakness of the neck and respiratory muscles, but patients with ocular myasthenia have not been described. Objective: To report a case of ocular myasthenia due to anti-MuSK antibodies. Patient: A young woman with ocular myasthenia and antibodies to MuSK. Results: Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen. Conclusion: Ocular myasthenia gravis is a presentation of the anti-MuSK antibody syndrome.

Original languageEnglish (US)
Pages (from-to)1002-1003
Number of pages2
JournalArchives of Neurology
Volume62
Issue number6
DOIs
StatePublished - Jun 2005
Externally publishedYes

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Myasthenia Gravis
Receptor Protein-Tyrosine Kinases
Muscles
Antibodies
Neck Muscles
Respiratory Muscles
Radioimmunoassay
Antigens

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Anti-MuSK myasthenia gravis presenting with purely ocular findings. / Caress, James B.; Hunt, Christopher H.; Batish, Sat Dev.

In: Archives of Neurology, Vol. 62, No. 6, 06.2005, p. 1002-1003.

Research output: Contribution to journalArticle

Caress, James B. ; Hunt, Christopher H. ; Batish, Sat Dev. / Anti-MuSK myasthenia gravis presenting with purely ocular findings. In: Archives of Neurology. 2005 ; Vol. 62, No. 6. pp. 1002-1003.
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