Anti-MuSK myasthenia gravis presenting with purely ocular findings

James B. Caress, Christopher H. Hunt, Sat Dev Batish

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Background: Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) have been found in approximately 40% of patients with generalized myasthenia gravis who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weakness of the neck and respiratory muscles, but patients with ocular myasthenia have not been described. Objective: To report a case of ocular myasthenia due to anti-MuSK antibodies. Patient: A young woman with ocular myasthenia and antibodies to MuSK. Results: Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen. Conclusion: Ocular myasthenia gravis is a presentation of the anti-MuSK antibody syndrome.

Original languageEnglish (US)
Pages (from-to)1002-1003
Number of pages2
JournalArchives of neurology
Volume62
Issue number6
DOIs
StatePublished - Jun 1 2005

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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