Anti-fouling strategies for central venous catheters

Alex Wallace, Hassan Albadawi, Nikasha Patel, Ali Khademhosseini, Yu Shrike Zhang, Sailendra Naidu, Grace Knuttinen, Rahmi Oklu

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Central venous catheters (CVCs) are ubiquitous in the healthcare industry and carry two common complications, catheter related infections and occlusion, particularly by thrombus. Catheter-related bloodstream infections (CRBSI) are an important cause of nosocomial infections that increase patient morbidity, mortality, and hospital cost. Innovative design strategies for intravenous catheters can help reduce these preventable infections. Antimicrobial coatings can play a major role in preventing disease. These coatings can be divided into two major categories: Drug eluting and non-drug eluting. Much of these catheter designs are targeted at preventing the formation of microbial biofilms that make treatment of CRBSI nearly impossible without removal of the intravenous device. Exciting developments in catheter impregnation with antibiotics as well as nanoscale surface design promise innovative changes in the way that physicians manage intravenous catheters. Occlusion of a catheter renders the catheter unusable and is often treated by tissue plasminogen activator administration or replacement of the line. Prevention of this complication requires a thorough understanding of the mechanisms of platelet aggregation, signaling and cross-linking. This article will look at the advances in biomaterial design specifically drug eluting, non-drug eluting, lubricious coatings and micropatterning as well as some of the characteristics of each as they relate to CVCs.

Original languageEnglish (US)
Pages (from-to)S246-S257
JournalCardiovascular Diagnosis and Therapy
Volume7
DOIs
StatePublished - Dec 1 2017

Fingerprint

Central Venous Catheters
Catheters
Catheter-Related Infections
Device Removal
Health Care Sector
Hospital Costs
Drug Design
Biocompatible Materials
Tissue Plasminogen Activator
Biofilms
Cross Infection
Platelet Aggregation
Thrombosis
Anti-Bacterial Agents
Morbidity
Physicians
Mortality
Infection
Pharmaceutical Preparations

Keywords

  • Biofouling
  • Catheters
  • Central venous catheters (CVCs)
  • Infections
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Anti-fouling strategies for central venous catheters. / Wallace, Alex; Albadawi, Hassan; Patel, Nikasha; Khademhosseini, Ali; Zhang, Yu Shrike; Naidu, Sailendra; Knuttinen, Grace; Oklu, Rahmi.

In: Cardiovascular Diagnosis and Therapy, Vol. 7, 01.12.2017, p. S246-S257.

Research output: Contribution to journalReview article

Wallace, Alex ; Albadawi, Hassan ; Patel, Nikasha ; Khademhosseini, Ali ; Zhang, Yu Shrike ; Naidu, Sailendra ; Knuttinen, Grace ; Oklu, Rahmi. / Anti-fouling strategies for central venous catheters. In: Cardiovascular Diagnosis and Therapy. 2017 ; Vol. 7. pp. S246-S257.
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