Anti-Aβ42- and anti-Aβ40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

Yona Levites, Pritam Das, Robert W. Price, Marjorie J. Rochette, Lisa A. Kostura, Eileen M. McGowan, Michael P. Murphy, Todd E. Golde

Research output: Contribution to journalArticlepeer-review

159 Scopus citations

Abstract

Accumulation and aggregation of amyloid β peptide 1-42 (Aβ42) in the brain has been hypothesized as triggering a pathological cascade that causes Alzheimer disease (AD). To determine whether selective targeting of Aβ42 versus Aβ40 or total Aβ is an effective way to prevent or treat AD, we compared the effects of passive immunization with an anti-Aβ42 mAb, an anti-Aβ40 mAb, and multiple Aβ1-16 mAbs. We established in vivo binding selectivity of the anti-Aβ42 and anti-Aβ40 mAbs using novel TgBRI-Aβ mice. We then conducted a prevention study in which the anti-Aβ mAbs were administered to young Tg2576 mice, which have no significant Aβ deposition, and therapeutic studies in which mAbs were administered to Tg2576 or CRND8 mice with modest levels of preexisting Aβ deposits. Anti-Aβ42, anti-Aβ40, and anti-Aβ1-16 mAbs attenuated plaque deposition in the prevention study. In contrast, anti- Aβ42 and anti-Aβ40 mAbs were less effective in attenuating Aβ deposition in the therapeutic studies and were not effective in clearing diffuse plaques following direct injection into the cortex. These data suggest that selective targeting of Aβ42 or Aβ40 may be an effective strategy to prevent amyloid deposition, but may have limited benefit in a therapeutic setting.

Original languageEnglish (US)
Pages (from-to)193-201
Number of pages9
JournalJournal of Clinical Investigation
Volume116
Issue number1
DOIs
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Medicine(all)

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