Anti-αβ-T-cell receptor antibodies in the setting of laryngeal transplantation

Marshall Strome, David G. Lott

Research output: Contribution to journalReview article

Abstract

Inhibiting T-cell activation is critically important to the induction of transplantation tolerance. Monoclonal antibodies directed against the α-T-cell receptor have been shown to cause selective immunodepletion of this T-cell population and can provide long-term allograft acceptance. This article discusses the role of this promising immunosuppressive agent in scientific research and clinical utilization. Specifically, the article focuses on its efficacy and mechanism of tolerance induction in solid tissue and composite tissue allograft transplantation with a particular focus on laryngeal transplantation.

Original languageEnglish (US)
Pages (from-to)835-845
Number of pages11
JournalImmunotherapy
Volume2
Issue number6
DOIs
StatePublished - Nov 1 2010

Keywords

  • anti-αβ-TCR antibody
  • chimerism
  • composite tissue allograft
  • laryngeal transplantation
  • tolerance
  • αβ-TCR

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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