Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in the Iowa Women's Health Study cohort

Alexis D. Leal, Carrie A Thompson, Alice H. Wang, Robert A. Vierkant, Thomas Matthew Habermann, Julie A. Ross, Ruben A. Mesa, Beth A. Virnig, James R Cerhan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Classical myeloproliferative neoplasms (MPNs) are composed of essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis (MF), the etiology of which is largely unknown. We investigated the role of anthropometric, medical and lifestyle factors with risk of MPN in a prospective cohort of 27,370 women aged 55-69 years at enrollment. After >250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV, 21 MF). Risk factor profiles were mostly unique for the two most common types, ET and PV. ET was associated with energy balance factors including body mass index (RR = 1.52 for >29.3 vs. <23.4 kg/m2; p-trend = 0.042), physical activity (RR = 0.66 for high vs. low; p-trend = 0.04) and adult onset diabetes (RR = 1.82; p = 0.009), while PV was not. PV was associated with current smoking (RR = 2.83; p-trend = 0.016), while ET was not. Regular use of aspirin was associated with lower risk of ET (RR = 0.68; p = 0.017). These results broadly held in multivariate models. Our results suggest distinct etiologies for these MPN subtypes and raise mechanistic hypotheses related to obesity-related inflammatory pathways for ET and smoking-related carcinogenic pathways for PV. Regular aspirin use may lower risk for ET. What's New? Myeloproliferative neoplasms (MPNs) are diseases of the blood and bone marrow that include conditions such as essential thrombocythemia (ET) and polycythemia vera (PV). The risk factors and pathogenesis of MPNs, however, are largely unknown. In this investigation of medical, lifestyle, and anthropometric factors, obesity, physical inactivity, and adult onset diabetes were found to be associated with a higher risk of ET, whereas current smoking was associated with a higher risk of PV. Regular aspirin use, on the other hand, may lower ET risk. The findings suggest distinct etiologies for the most common MPN subtypes, ET and PV.

Original languageEnglish (US)
Pages (from-to)1741-1750
Number of pages10
JournalInternational Journal of Cancer
Volume134
Issue number7
DOIs
StatePublished - Apr 1 2014

Fingerprint

Essential Thrombocythemia
Women's Health
Polycythemia Vera
Life Style
Cohort Studies
Neoplasms
Aspirin
Primary Myelofibrosis
Smoking
Obesity
Bone Marrow Diseases
Body Mass Index

Keywords

  • essential thrombocythemia
  • lifestyle
  • myeloproliferative neoplasm
  • polycythemia vera
  • risk factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in the Iowa Women's Health Study cohort. / Leal, Alexis D.; Thompson, Carrie A; Wang, Alice H.; Vierkant, Robert A.; Habermann, Thomas Matthew; Ross, Julie A.; Mesa, Ruben A.; Virnig, Beth A.; Cerhan, James R.

In: International Journal of Cancer, Vol. 134, No. 7, 01.04.2014, p. 1741-1750.

Research output: Contribution to journalArticle

Leal, Alexis D. ; Thompson, Carrie A ; Wang, Alice H. ; Vierkant, Robert A. ; Habermann, Thomas Matthew ; Ross, Julie A. ; Mesa, Ruben A. ; Virnig, Beth A. ; Cerhan, James R. / Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in the Iowa Women's Health Study cohort. In: International Journal of Cancer. 2014 ; Vol. 134, No. 7. pp. 1741-1750.
@article{a0cf927c73c8428c8fefcbdfee657dbb,
title = "Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in the Iowa Women's Health Study cohort",
abstract = "Classical myeloproliferative neoplasms (MPNs) are composed of essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis (MF), the etiology of which is largely unknown. We investigated the role of anthropometric, medical and lifestyle factors with risk of MPN in a prospective cohort of 27,370 women aged 55-69 years at enrollment. After >250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV, 21 MF). Risk factor profiles were mostly unique for the two most common types, ET and PV. ET was associated with energy balance factors including body mass index (RR = 1.52 for >29.3 vs. <23.4 kg/m2; p-trend = 0.042), physical activity (RR = 0.66 for high vs. low; p-trend = 0.04) and adult onset diabetes (RR = 1.82; p = 0.009), while PV was not. PV was associated with current smoking (RR = 2.83; p-trend = 0.016), while ET was not. Regular use of aspirin was associated with lower risk of ET (RR = 0.68; p = 0.017). These results broadly held in multivariate models. Our results suggest distinct etiologies for these MPN subtypes and raise mechanistic hypotheses related to obesity-related inflammatory pathways for ET and smoking-related carcinogenic pathways for PV. Regular aspirin use may lower risk for ET. What's New? Myeloproliferative neoplasms (MPNs) are diseases of the blood and bone marrow that include conditions such as essential thrombocythemia (ET) and polycythemia vera (PV). The risk factors and pathogenesis of MPNs, however, are largely unknown. In this investigation of medical, lifestyle, and anthropometric factors, obesity, physical inactivity, and adult onset diabetes were found to be associated with a higher risk of ET, whereas current smoking was associated with a higher risk of PV. Regular aspirin use, on the other hand, may lower ET risk. The findings suggest distinct etiologies for the most common MPN subtypes, ET and PV.",
keywords = "essential thrombocythemia, lifestyle, myeloproliferative neoplasm, polycythemia vera, risk factor",
author = "Leal, {Alexis D.} and Thompson, {Carrie A} and Wang, {Alice H.} and Vierkant, {Robert A.} and Habermann, {Thomas Matthew} and Ross, {Julie A.} and Mesa, {Ruben A.} and Virnig, {Beth A.} and Cerhan, {James R}",
year = "2014",
month = "4",
day = "1",
doi = "10.1002/ijc.28492",
language = "English (US)",
volume = "134",
pages = "1741--1750",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in the Iowa Women's Health Study cohort

AU - Leal, Alexis D.

AU - Thompson, Carrie A

AU - Wang, Alice H.

AU - Vierkant, Robert A.

AU - Habermann, Thomas Matthew

AU - Ross, Julie A.

AU - Mesa, Ruben A.

AU - Virnig, Beth A.

AU - Cerhan, James R

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Classical myeloproliferative neoplasms (MPNs) are composed of essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis (MF), the etiology of which is largely unknown. We investigated the role of anthropometric, medical and lifestyle factors with risk of MPN in a prospective cohort of 27,370 women aged 55-69 years at enrollment. After >250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV, 21 MF). Risk factor profiles were mostly unique for the two most common types, ET and PV. ET was associated with energy balance factors including body mass index (RR = 1.52 for >29.3 vs. <23.4 kg/m2; p-trend = 0.042), physical activity (RR = 0.66 for high vs. low; p-trend = 0.04) and adult onset diabetes (RR = 1.82; p = 0.009), while PV was not. PV was associated with current smoking (RR = 2.83; p-trend = 0.016), while ET was not. Regular use of aspirin was associated with lower risk of ET (RR = 0.68; p = 0.017). These results broadly held in multivariate models. Our results suggest distinct etiologies for these MPN subtypes and raise mechanistic hypotheses related to obesity-related inflammatory pathways for ET and smoking-related carcinogenic pathways for PV. Regular aspirin use may lower risk for ET. What's New? Myeloproliferative neoplasms (MPNs) are diseases of the blood and bone marrow that include conditions such as essential thrombocythemia (ET) and polycythemia vera (PV). The risk factors and pathogenesis of MPNs, however, are largely unknown. In this investigation of medical, lifestyle, and anthropometric factors, obesity, physical inactivity, and adult onset diabetes were found to be associated with a higher risk of ET, whereas current smoking was associated with a higher risk of PV. Regular aspirin use, on the other hand, may lower ET risk. The findings suggest distinct etiologies for the most common MPN subtypes, ET and PV.

AB - Classical myeloproliferative neoplasms (MPNs) are composed of essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis (MF), the etiology of which is largely unknown. We investigated the role of anthropometric, medical and lifestyle factors with risk of MPN in a prospective cohort of 27,370 women aged 55-69 years at enrollment. After >250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV, 21 MF). Risk factor profiles were mostly unique for the two most common types, ET and PV. ET was associated with energy balance factors including body mass index (RR = 1.52 for >29.3 vs. <23.4 kg/m2; p-trend = 0.042), physical activity (RR = 0.66 for high vs. low; p-trend = 0.04) and adult onset diabetes (RR = 1.82; p = 0.009), while PV was not. PV was associated with current smoking (RR = 2.83; p-trend = 0.016), while ET was not. Regular use of aspirin was associated with lower risk of ET (RR = 0.68; p = 0.017). These results broadly held in multivariate models. Our results suggest distinct etiologies for these MPN subtypes and raise mechanistic hypotheses related to obesity-related inflammatory pathways for ET and smoking-related carcinogenic pathways for PV. Regular aspirin use may lower risk for ET. What's New? Myeloproliferative neoplasms (MPNs) are diseases of the blood and bone marrow that include conditions such as essential thrombocythemia (ET) and polycythemia vera (PV). The risk factors and pathogenesis of MPNs, however, are largely unknown. In this investigation of medical, lifestyle, and anthropometric factors, obesity, physical inactivity, and adult onset diabetes were found to be associated with a higher risk of ET, whereas current smoking was associated with a higher risk of PV. Regular aspirin use, on the other hand, may lower ET risk. The findings suggest distinct etiologies for the most common MPN subtypes, ET and PV.

KW - essential thrombocythemia

KW - lifestyle

KW - myeloproliferative neoplasm

KW - polycythemia vera

KW - risk factor

UR - http://www.scopus.com/inward/record.url?scp=84892612635&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892612635&partnerID=8YFLogxK

U2 - 10.1002/ijc.28492

DO - 10.1002/ijc.28492

M3 - Article

C2 - 24114627

AN - SCOPUS:84892612635

VL - 134

SP - 1741

EP - 1750

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 7

ER -