Anthropometric measures, body mass index, and pancreatic cancer

A pooled analysis from the pancreatic cancer cohort consortium (PanScan)

Alan A. Arslan, Kathy J. Helzlsouer, Charles Kooperberg, Xiao Ou Shu, Emily Steplowski, H. Bas Bueno-De-Mesquita, Charles S. Fuchs, Myron D. Gross, Eric J. Jacobs, Andrea Z. LaCroix, Gloria M Petersen, Rachael Z. Stolzenberg-Solomon, Wei Zheng, Demetrius Albanes, Laufey Amundadottir, William R. Bamlet, Aurelio Barricarte, Sheila A. Bingham, Heiner Boeing, Marie Christine Boutron-Ruault & 31 others Julie E. Buring, Stephen J. Chanock, Sandra Clipp, J. Michael Gaziano, Edward L. Giovannucci, Susan E. Hankinson, Patricia Hartge, Robert N. Hoover, David J. Hunter, Amy Hutchinson, Kevin B. Jacobs, Peter Kraft, Shannon M. Lynch, Jonas Manjer, JoAnn E. Manson, Anne McTiernan, Robert R Mc Williams, Julie B. Mendelsohn, Dominique S. Michaud, Domenico Palli, Thomas E. Rohan, Nadia Slimani, Gilles Thomas, Anne Tjønneland, Geoffrey S. Tobias, Dimitrios Trichopoulos, Jarmo Virtamo, Brian M. Wolpin, Kai Yu, Anne Zeleniuch-Jacquotte, Alpa V. Patel

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohortspecific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese,≥35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjustedORfor the highest vs lowest BMI quartile, 1.33; 95% CI, 1.12-1.58; Ptrend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% CI, 1.04-1.69; Ptrend<.03), and in women it was 1.34 (95% CI, 1.05-1.70; Ptrend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% CI, 1.31-2.69; Ptrend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.

Original languageEnglish (US)
Pages (from-to)791-802
Number of pages12
JournalArchives of Internal Medicine
Volume170
Issue number9
DOIs
StatePublished - May 10 2010

Fingerprint

Pancreatic Neoplasms
Body Mass Index
Confidence Intervals
Waist-Hip Ratio
Odds Ratio
Weights and Measures
National Cancer Institute (U.S.)
Thinness
Waist Circumference
Case-Control Studies
Obesity
Logistic Models
Fats

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Arslan, A. A., Helzlsouer, K. J., Kooperberg, C., Shu, X. O., Steplowski, E., Bueno-De-Mesquita, H. B., ... Patel, A. V. (2010). Anthropometric measures, body mass index, and pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium (PanScan). Archives of Internal Medicine, 170(9), 791-802. https://doi.org/10.1001/archinternmed.2010.63

Anthropometric measures, body mass index, and pancreatic cancer : A pooled analysis from the pancreatic cancer cohort consortium (PanScan). / Arslan, Alan A.; Helzlsouer, Kathy J.; Kooperberg, Charles; Shu, Xiao Ou; Steplowski, Emily; Bueno-De-Mesquita, H. Bas; Fuchs, Charles S.; Gross, Myron D.; Jacobs, Eric J.; LaCroix, Andrea Z.; Petersen, Gloria M; Stolzenberg-Solomon, Rachael Z.; Zheng, Wei; Albanes, Demetrius; Amundadottir, Laufey; Bamlet, William R.; Barricarte, Aurelio; Bingham, Sheila A.; Boeing, Heiner; Boutron-Ruault, Marie Christine; Buring, Julie E.; Chanock, Stephen J.; Clipp, Sandra; Gaziano, J. Michael; Giovannucci, Edward L.; Hankinson, Susan E.; Hartge, Patricia; Hoover, Robert N.; Hunter, David J.; Hutchinson, Amy; Jacobs, Kevin B.; Kraft, Peter; Lynch, Shannon M.; Manjer, Jonas; Manson, JoAnn E.; McTiernan, Anne; Mc Williams, Robert R; Mendelsohn, Julie B.; Michaud, Dominique S.; Palli, Domenico; Rohan, Thomas E.; Slimani, Nadia; Thomas, Gilles; Tjønneland, Anne; Tobias, Geoffrey S.; Trichopoulos, Dimitrios; Virtamo, Jarmo; Wolpin, Brian M.; Yu, Kai; Zeleniuch-Jacquotte, Anne; Patel, Alpa V.

In: Archives of Internal Medicine, Vol. 170, No. 9, 10.05.2010, p. 791-802.

Research output: Contribution to journalArticle

Arslan, AA, Helzlsouer, KJ, Kooperberg, C, Shu, XO, Steplowski, E, Bueno-De-Mesquita, HB, Fuchs, CS, Gross, MD, Jacobs, EJ, LaCroix, AZ, Petersen, GM, Stolzenberg-Solomon, RZ, Zheng, W, Albanes, D, Amundadottir, L, Bamlet, WR, Barricarte, A, Bingham, SA, Boeing, H, Boutron-Ruault, MC, Buring, JE, Chanock, SJ, Clipp, S, Gaziano, JM, Giovannucci, EL, Hankinson, SE, Hartge, P, Hoover, RN, Hunter, DJ, Hutchinson, A, Jacobs, KB, Kraft, P, Lynch, SM, Manjer, J, Manson, JE, McTiernan, A, Mc Williams, RR, Mendelsohn, JB, Michaud, DS, Palli, D, Rohan, TE, Slimani, N, Thomas, G, Tjønneland, A, Tobias, GS, Trichopoulos, D, Virtamo, J, Wolpin, BM, Yu, K, Zeleniuch-Jacquotte, A & Patel, AV 2010, 'Anthropometric measures, body mass index, and pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium (PanScan)', Archives of Internal Medicine, vol. 170, no. 9, pp. 791-802. https://doi.org/10.1001/archinternmed.2010.63
Arslan, Alan A. ; Helzlsouer, Kathy J. ; Kooperberg, Charles ; Shu, Xiao Ou ; Steplowski, Emily ; Bueno-De-Mesquita, H. Bas ; Fuchs, Charles S. ; Gross, Myron D. ; Jacobs, Eric J. ; LaCroix, Andrea Z. ; Petersen, Gloria M ; Stolzenberg-Solomon, Rachael Z. ; Zheng, Wei ; Albanes, Demetrius ; Amundadottir, Laufey ; Bamlet, William R. ; Barricarte, Aurelio ; Bingham, Sheila A. ; Boeing, Heiner ; Boutron-Ruault, Marie Christine ; Buring, Julie E. ; Chanock, Stephen J. ; Clipp, Sandra ; Gaziano, J. Michael ; Giovannucci, Edward L. ; Hankinson, Susan E. ; Hartge, Patricia ; Hoover, Robert N. ; Hunter, David J. ; Hutchinson, Amy ; Jacobs, Kevin B. ; Kraft, Peter ; Lynch, Shannon M. ; Manjer, Jonas ; Manson, JoAnn E. ; McTiernan, Anne ; Mc Williams, Robert R ; Mendelsohn, Julie B. ; Michaud, Dominique S. ; Palli, Domenico ; Rohan, Thomas E. ; Slimani, Nadia ; Thomas, Gilles ; Tjønneland, Anne ; Tobias, Geoffrey S. ; Trichopoulos, Dimitrios ; Virtamo, Jarmo ; Wolpin, Brian M. ; Yu, Kai ; Zeleniuch-Jacquotte, Anne ; Patel, Alpa V. / Anthropometric measures, body mass index, and pancreatic cancer : A pooled analysis from the pancreatic cancer cohort consortium (PanScan). In: Archives of Internal Medicine. 2010 ; Vol. 170, No. 9. pp. 791-802.
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title = "Anthropometric measures, body mass index, and pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium (PanScan)",
abstract = "Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were estimated using unconditional logistic regression for cohortspecific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese,≥35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjustedORfor the highest vs lowest BMI quartile, 1.33; 95{\%} CI, 1.12-1.58; Ptrend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95{\%} CI, 1.04-1.69; Ptrend<.03), and in women it was 1.34 (95{\%} CI, 1.05-1.70; Ptrend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95{\%} CI, 1.31-2.69; Ptrend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.",
author = "Arslan, {Alan A.} and Helzlsouer, {Kathy J.} and Charles Kooperberg and Shu, {Xiao Ou} and Emily Steplowski and Bueno-De-Mesquita, {H. Bas} and Fuchs, {Charles S.} and Gross, {Myron D.} and Jacobs, {Eric J.} and LaCroix, {Andrea Z.} and Petersen, {Gloria M} and Stolzenberg-Solomon, {Rachael Z.} and Wei Zheng and Demetrius Albanes and Laufey Amundadottir and Bamlet, {William R.} and Aurelio Barricarte and Bingham, {Sheila A.} and Heiner Boeing and Boutron-Ruault, {Marie Christine} and Buring, {Julie E.} and Chanock, {Stephen J.} and Sandra Clipp and Gaziano, {J. Michael} and Giovannucci, {Edward L.} and Hankinson, {Susan E.} and Patricia Hartge and Hoover, {Robert N.} and Hunter, {David J.} and Amy Hutchinson and Jacobs, {Kevin B.} and Peter Kraft and Lynch, {Shannon M.} and Jonas Manjer and Manson, {JoAnn E.} and Anne McTiernan and {Mc Williams}, {Robert R} and Mendelsohn, {Julie B.} and Michaud, {Dominique S.} and Domenico Palli and Rohan, {Thomas E.} and Nadia Slimani and Gilles Thomas and Anne Tj{\o}nneland and Tobias, {Geoffrey S.} and Dimitrios Trichopoulos and Jarmo Virtamo and Wolpin, {Brian M.} and Kai Yu and Anne Zeleniuch-Jacquotte and Patel, {Alpa V.}",
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TY - JOUR

T1 - Anthropometric measures, body mass index, and pancreatic cancer

T2 - A pooled analysis from the pancreatic cancer cohort consortium (PanScan)

AU - Arslan, Alan A.

AU - Helzlsouer, Kathy J.

AU - Kooperberg, Charles

AU - Shu, Xiao Ou

AU - Steplowski, Emily

AU - Bueno-De-Mesquita, H. Bas

AU - Fuchs, Charles S.

AU - Gross, Myron D.

AU - Jacobs, Eric J.

AU - LaCroix, Andrea Z.

AU - Petersen, Gloria M

AU - Stolzenberg-Solomon, Rachael Z.

AU - Zheng, Wei

AU - Albanes, Demetrius

AU - Amundadottir, Laufey

AU - Bamlet, William R.

AU - Barricarte, Aurelio

AU - Bingham, Sheila A.

AU - Boeing, Heiner

AU - Boutron-Ruault, Marie Christine

AU - Buring, Julie E.

AU - Chanock, Stephen J.

AU - Clipp, Sandra

AU - Gaziano, J. Michael

AU - Giovannucci, Edward L.

AU - Hankinson, Susan E.

AU - Hartge, Patricia

AU - Hoover, Robert N.

AU - Hunter, David J.

AU - Hutchinson, Amy

AU - Jacobs, Kevin B.

AU - Kraft, Peter

AU - Lynch, Shannon M.

AU - Manjer, Jonas

AU - Manson, JoAnn E.

AU - McTiernan, Anne

AU - Mc Williams, Robert R

AU - Mendelsohn, Julie B.

AU - Michaud, Dominique S.

AU - Palli, Domenico

AU - Rohan, Thomas E.

AU - Slimani, Nadia

AU - Thomas, Gilles

AU - Tjønneland, Anne

AU - Tobias, Geoffrey S.

AU - Trichopoulos, Dimitrios

AU - Virtamo, Jarmo

AU - Wolpin, Brian M.

AU - Yu, Kai

AU - Zeleniuch-Jacquotte, Anne

AU - Patel, Alpa V.

PY - 2010/5/10

Y1 - 2010/5/10

N2 - Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohortspecific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese,≥35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjustedORfor the highest vs lowest BMI quartile, 1.33; 95% CI, 1.12-1.58; Ptrend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% CI, 1.04-1.69; Ptrend<.03), and in women it was 1.34 (95% CI, 1.05-1.70; Ptrend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% CI, 1.31-2.69; Ptrend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.

AB - Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohortspecific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese,≥35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjustedORfor the highest vs lowest BMI quartile, 1.33; 95% CI, 1.12-1.58; Ptrend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% CI, 1.04-1.69; Ptrend<.03), and in women it was 1.34 (95% CI, 1.05-1.70; Ptrend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% CI, 1.31-2.69; Ptrend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.

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