TY - JOUR
T1 - Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma subtypes and B-cell chronic lymphocytic leukemia
T2 - A prospective study
AU - Cerhan, James R.
AU - Janney, Carol A.
AU - Vachon, Celine M.
AU - Habermann, Thomas M.
AU - Kay, Neil E.
AU - Potter, John D.
AU - Sellers, Thomas A.
AU - Folsom, Aaron R.
N1 - Funding Information:
The Iowa Women’s Health Study was supported by National Cancer Institute grant R01 CA39741. Dr. Cerhan was supported in part by a National Cancer Institute Preventive Oncology Award (K07 CA64220).
PY - 2002/9/15
Y1 - 2002/9/15
N2 - Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma, its subtypes, and B-cell chronic lymphocytic leukemia (B-CLL) were evaluated in a prospective cohort study of 37,931 Iowa women who were aged 55-69 years at baseline in 1986. Through 1998, 261 cases of non-Hodgkin's lymphoma (137 diffuse, 58 follicular, and 32 small lymphocytic lymphomas) and 63 cases of B-CLL were identified by linkage to the Iowa Cancer Registry. Height, weight, body mass index, waist/hip ratio, and physical activity were not associated with risk of non-Hodgkin's lymphoma overall or with diffuse or follicular lymphoma in particular. After adjustment for other non-Hodgkin's lymphoma risk factors, there was an inverse association of baseline body mass index (relative risks (RRs) across quartiles: 1, 0.4, 0.4, 0.3; ptrend = 0.03) with risk of small lymphocytic lymphoma. In contrast, for B-CLL there were suggestive positive associations with body mass index at age 50 years (RRs across quartiles: 1, 1.9, 1.5, 2.7; p trend = 0.03) and (more weakly) baseline body mass index (RRs across quartiles: 1, 1.1, 1.6, 1.3; p trend = 0.3). In summary, we found no evidence that height, weight, body mass, or physical activity plays an important role in non-Hodgkin's lymphoma overall or in diffuse or follicular lymphoma in particular. The opposite associations of body mass index with small lymphocytic lymphoma versus B-CLL may be a chance finding but, if confirmed, would suggest different etiologies for these malignancies.
AB - Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma, its subtypes, and B-cell chronic lymphocytic leukemia (B-CLL) were evaluated in a prospective cohort study of 37,931 Iowa women who were aged 55-69 years at baseline in 1986. Through 1998, 261 cases of non-Hodgkin's lymphoma (137 diffuse, 58 follicular, and 32 small lymphocytic lymphomas) and 63 cases of B-CLL were identified by linkage to the Iowa Cancer Registry. Height, weight, body mass index, waist/hip ratio, and physical activity were not associated with risk of non-Hodgkin's lymphoma overall or with diffuse or follicular lymphoma in particular. After adjustment for other non-Hodgkin's lymphoma risk factors, there was an inverse association of baseline body mass index (relative risks (RRs) across quartiles: 1, 0.4, 0.4, 0.3; ptrend = 0.03) with risk of small lymphocytic lymphoma. In contrast, for B-CLL there were suggestive positive associations with body mass index at age 50 years (RRs across quartiles: 1, 1.9, 1.5, 2.7; p trend = 0.03) and (more weakly) baseline body mass index (RRs across quartiles: 1, 1.1, 1.6, 1.3; p trend = 0.3). In summary, we found no evidence that height, weight, body mass, or physical activity plays an important role in non-Hodgkin's lymphoma overall or in diffuse or follicular lymphoma in particular. The opposite associations of body mass index with small lymphocytic lymphoma versus B-CLL may be a chance finding but, if confirmed, would suggest different etiologies for these malignancies.
KW - Anthropometry
KW - Cohort studies
KW - Leukemia, lymphocytic, chronic
KW - Lymphoma, non-Hodgkin
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U2 - 10.1093/aje/kwf082
DO - 10.1093/aje/kwf082
M3 - Article
C2 - 12226000
AN - SCOPUS:0037105595
SN - 0002-9262
VL - 156
SP - 527
EP - 535
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 6
ER -