Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma subtypes and B-cell chronic lymphocytic leukemia: A prospective study

James R Cerhan, Carol A. Janney, Celine M Vachon, Thomas Matthew Habermann, Neil Elliot Kay, John D. Potter, Thomas A. Sellers, Aaron R. Folsom

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Abstract

Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma, its subtypes, and B-cell chronic lymphocytic leukemia (B-CLL) were evaluated in a prospective cohort study of 37,931 Iowa women who were aged 55-69 years at baseline in 1986. Through 1998, 261 cases of non-Hodgkin's lymphoma (137 diffuse, 58 follicular, and 32 small lymphocytic lymphomas) and 63 cases of B-CLL were identified by linkage to the Iowa Cancer Registry. Height, weight, body mass index, waist/hip ratio, and physical activity were not associated with risk of non-Hodgkin's lymphoma overall or with diffuse or follicular lymphoma in particular. After adjustment for other non-Hodgkin's lymphoma risk factors, there was an inverse association of baseline body mass index (relative risks (RRs) across quartiles: 1, 0.4, 0.4, 0.3; ptrend = 0.03) with risk of small lymphocytic lymphoma. In contrast, for B-CLL there were suggestive positive associations with body mass index at age 50 years (RRs across quartiles: 1, 1.9, 1.5, 2.7; p trend = 0.03) and (more weakly) baseline body mass index (RRs across quartiles: 1, 1.1, 1.6, 1.3; p trend = 0.3). In summary, we found no evidence that height, weight, body mass, or physical activity plays an important role in non-Hodgkin's lymphoma overall or in diffuse or follicular lymphoma in particular. The opposite associations of body mass index with small lymphocytic lymphoma versus B-CLL may be a chance finding but, if confirmed, would suggest different etiologies for these malignancies.

Original languageEnglish (US)
Pages (from-to)527-535
Number of pages9
JournalAmerican Journal of Epidemiology
Volume156
Issue number6
DOIs
StatePublished - Sep 15 2002

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B-Cell Chronic Lymphocytic Leukemia
Non-Hodgkin's Lymphoma
Prospective Studies
Exercise
Body Mass Index
Follicular Lymphoma
Body Height
Waist-Hip Ratio
Registries
Neoplasms
Cohort Studies
Body Weight
Weights and Measures

Keywords

  • Anthropometry
  • Cohort studies
  • Leukemia, lymphocytic, chronic
  • Lymphoma, non-Hodgkin

ASJC Scopus subject areas

  • Epidemiology

Cite this

@article{5a02500c81264bc1b63089884ee7fb12,
title = "Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma subtypes and B-cell chronic lymphocytic leukemia: A prospective study",
abstract = "Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma, its subtypes, and B-cell chronic lymphocytic leukemia (B-CLL) were evaluated in a prospective cohort study of 37,931 Iowa women who were aged 55-69 years at baseline in 1986. Through 1998, 261 cases of non-Hodgkin's lymphoma (137 diffuse, 58 follicular, and 32 small lymphocytic lymphomas) and 63 cases of B-CLL were identified by linkage to the Iowa Cancer Registry. Height, weight, body mass index, waist/hip ratio, and physical activity were not associated with risk of non-Hodgkin's lymphoma overall or with diffuse or follicular lymphoma in particular. After adjustment for other non-Hodgkin's lymphoma risk factors, there was an inverse association of baseline body mass index (relative risks (RRs) across quartiles: 1, 0.4, 0.4, 0.3; ptrend = 0.03) with risk of small lymphocytic lymphoma. In contrast, for B-CLL there were suggestive positive associations with body mass index at age 50 years (RRs across quartiles: 1, 1.9, 1.5, 2.7; p trend = 0.03) and (more weakly) baseline body mass index (RRs across quartiles: 1, 1.1, 1.6, 1.3; p trend = 0.3). In summary, we found no evidence that height, weight, body mass, or physical activity plays an important role in non-Hodgkin's lymphoma overall or in diffuse or follicular lymphoma in particular. The opposite associations of body mass index with small lymphocytic lymphoma versus B-CLL may be a chance finding but, if confirmed, would suggest different etiologies for these malignancies.",
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author = "Cerhan, {James R} and Janney, {Carol A.} and Vachon, {Celine M} and Habermann, {Thomas Matthew} and Kay, {Neil Elliot} and Potter, {John D.} and Sellers, {Thomas A.} and Folsom, {Aaron R.}",
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T1 - Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma subtypes and B-cell chronic lymphocytic leukemia

T2 - A prospective study

AU - Cerhan, James R

AU - Janney, Carol A.

AU - Vachon, Celine M

AU - Habermann, Thomas Matthew

AU - Kay, Neil Elliot

AU - Potter, John D.

AU - Sellers, Thomas A.

AU - Folsom, Aaron R.

PY - 2002/9/15

Y1 - 2002/9/15

N2 - Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma, its subtypes, and B-cell chronic lymphocytic leukemia (B-CLL) were evaluated in a prospective cohort study of 37,931 Iowa women who were aged 55-69 years at baseline in 1986. Through 1998, 261 cases of non-Hodgkin's lymphoma (137 diffuse, 58 follicular, and 32 small lymphocytic lymphomas) and 63 cases of B-CLL were identified by linkage to the Iowa Cancer Registry. Height, weight, body mass index, waist/hip ratio, and physical activity were not associated with risk of non-Hodgkin's lymphoma overall or with diffuse or follicular lymphoma in particular. After adjustment for other non-Hodgkin's lymphoma risk factors, there was an inverse association of baseline body mass index (relative risks (RRs) across quartiles: 1, 0.4, 0.4, 0.3; ptrend = 0.03) with risk of small lymphocytic lymphoma. In contrast, for B-CLL there were suggestive positive associations with body mass index at age 50 years (RRs across quartiles: 1, 1.9, 1.5, 2.7; p trend = 0.03) and (more weakly) baseline body mass index (RRs across quartiles: 1, 1.1, 1.6, 1.3; p trend = 0.3). In summary, we found no evidence that height, weight, body mass, or physical activity plays an important role in non-Hodgkin's lymphoma overall or in diffuse or follicular lymphoma in particular. The opposite associations of body mass index with small lymphocytic lymphoma versus B-CLL may be a chance finding but, if confirmed, would suggest different etiologies for these malignancies.

AB - Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma, its subtypes, and B-cell chronic lymphocytic leukemia (B-CLL) were evaluated in a prospective cohort study of 37,931 Iowa women who were aged 55-69 years at baseline in 1986. Through 1998, 261 cases of non-Hodgkin's lymphoma (137 diffuse, 58 follicular, and 32 small lymphocytic lymphomas) and 63 cases of B-CLL were identified by linkage to the Iowa Cancer Registry. Height, weight, body mass index, waist/hip ratio, and physical activity were not associated with risk of non-Hodgkin's lymphoma overall or with diffuse or follicular lymphoma in particular. After adjustment for other non-Hodgkin's lymphoma risk factors, there was an inverse association of baseline body mass index (relative risks (RRs) across quartiles: 1, 0.4, 0.4, 0.3; ptrend = 0.03) with risk of small lymphocytic lymphoma. In contrast, for B-CLL there were suggestive positive associations with body mass index at age 50 years (RRs across quartiles: 1, 1.9, 1.5, 2.7; p trend = 0.03) and (more weakly) baseline body mass index (RRs across quartiles: 1, 1.1, 1.6, 1.3; p trend = 0.3). In summary, we found no evidence that height, weight, body mass, or physical activity plays an important role in non-Hodgkin's lymphoma overall or in diffuse or follicular lymphoma in particular. The opposite associations of body mass index with small lymphocytic lymphoma versus B-CLL may be a chance finding but, if confirmed, would suggest different etiologies for these malignancies.

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