Anthropometric characteristics and risk of multiple myeloma

Cindy K. Blair, James R Cerhan, Aaron R. Folsom, Julie A. Ross

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: Few studies have examined obesity and risk for multiple myeloma, and the results are inconsistent. Laboratory evidence suggests mechanisms through which obesity could influence carcinogenesis of this hematopoietic malignancy. Methods: We examined the association between anthropometric characteristics and incident multiple myeloma in a prospective, population-based sample of 37,083 postmenopausal women. In 1986, the women completed a mailed questionnaire that included self-report of height and weight, and friend measurement of waist and hip circumferences. During 16 years of follow up, 95 cases of multiple myeloma were identified through linkage to the Iowa Cancer Registry. Results: In an age-adjusted model, women in the highest category of several anthropometric measurements compared with the lowest category were at increased risk of developing multiple myeloma. For body mass index (kg/m2), the rate ratio (95% confidence interval) was 1.5 (0.92-2.6); for weight, 1.9 (1.1-3.4); for waist circumference, 2.0 (1.1-3.5); and for hip circumference, 1.8 (1.0-3.0). Conclusion: Greater adiposity may increase the risk of multiple myeloma.

Original languageEnglish (US)
Pages (from-to)691-694
Number of pages4
JournalEpidemiology
Volume16
Issue number5
DOIs
StatePublished - Sep 2005

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Multiple Myeloma
Waist Circumference
Hip
Obesity
Weights and Measures
Adiposity
Hematologic Neoplasms
Self Report
Registries
Carcinogenesis
Body Mass Index
Confidence Intervals
Population
Neoplasms

ASJC Scopus subject areas

  • Epidemiology

Cite this

Anthropometric characteristics and risk of multiple myeloma. / Blair, Cindy K.; Cerhan, James R; Folsom, Aaron R.; Ross, Julie A.

In: Epidemiology, Vol. 16, No. 5, 09.2005, p. 691-694.

Research output: Contribution to journalArticle

Blair, Cindy K. ; Cerhan, James R ; Folsom, Aaron R. ; Ross, Julie A. / Anthropometric characteristics and risk of multiple myeloma. In: Epidemiology. 2005 ; Vol. 16, No. 5. pp. 691-694.
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