Anterior Thalamic Deep Brain Stimulation: Functional Activation Patterns in a Large Animal Model

William S. Gibson; Erika K. Ross; Seong Rok Han; Jamie J. Van Gompel; Hoon Ki Min; Kendall H. Lee

doi:10.1016/j.brs.2016.04.012

Anterior Thalamic Deep Brain Stimulation: Functional Activation Patterns in a Large Animal Model

William S. Gibson, Erika K. Ross, Seong Rok Han, Jamie J. Van Gompel, Hoon Ki Min, Kendall H. Lee

Neurosurgery

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background Deep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) exerts its effects by modulating neural circuits involved in seizures. However, these networks remain incompletely characterized. Objective Investigate the effects of ATN DBS on network activity in a large animal model using 3-T fMRI. Methods Anesthetized swine underwent ATN DBS using stimulation parameters applied in the Stimulation of the Anterior Thalamus for the Treatment of Epilepsy (SANTE) trial. Stimulation amplitude, frequency, and temporal paradigm were varied and the resulting blood oxygen level-dependent signal was measured. Results ATN DBS resulted in activation within temporal, prefrontal, and sensorimotor cortex. An amplitude-dependent increase in cluster volume was observed at 60 Hz and 145 Hz stimulation. Conclusion ATN DBS in swine induced parameter-dependent activation in cortical regions including but not limited to the Papez circuit. These findings may hold clinical implications for treatment of epilepsy in patients with temporal or extratemporal seizure foci.

Original language	English (US)
Pages (from-to)	770-773
Number of pages	4
Journal	Brain Stimulation
Volume	9
Issue number	5
DOIs	https://doi.org/10.1016/j.brs.2016.04.012
State	Published - Sep 1 2016

Keywords

Anterior thalamic nucleus
Deep brain stimulation
Epilepsy
fMRI

ASJC Scopus subject areas

Biophysics
Neuroscience(all)
Clinical Neurology

Access to Document

10.1016/j.brs.2016.04.012

Cite this

@article{eebfc53725ca484ba60ebf3a09a41350,

title = "Anterior Thalamic Deep Brain Stimulation: Functional Activation Patterns in a Large Animal Model",

abstract = "Background Deep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) exerts its effects by modulating neural circuits involved in seizures. However, these networks remain incompletely characterized. Objective Investigate the effects of ATN DBS on network activity in a large animal model using 3-T fMRI. Methods Anesthetized swine underwent ATN DBS using stimulation parameters applied in the Stimulation of the Anterior Thalamus for the Treatment of Epilepsy (SANTE) trial. Stimulation amplitude, frequency, and temporal paradigm were varied and the resulting blood oxygen level-dependent signal was measured. Results ATN DBS resulted in activation within temporal, prefrontal, and sensorimotor cortex. An amplitude-dependent increase in cluster volume was observed at 60 Hz and 145 Hz stimulation. Conclusion ATN DBS in swine induced parameter-dependent activation in cortical regions including but not limited to the Papez circuit. These findings may hold clinical implications for treatment of epilepsy in patients with temporal or extratemporal seizure foci.",

keywords = "Anterior thalamic nucleus, Deep brain stimulation, Epilepsy, fMRI",

author = "Gibson, {William S.} and Ross, {Erika K.} and Han, {Seong Rok} and {Van Gompel}, {Jamie J.} and Min, {Hoon Ki} and Lee, {Kendall H.}",

note = "Funding Information: This work was supported by the National Institutes of Health ( R01 NS 70872 awards to KHL) and the The Grainger Foundation . Publisher Copyright: {\textcopyright} 2016",

year = "2016",

month = sep,

day = "1",

doi = "10.1016/j.brs.2016.04.012",

language = "English (US)",

volume = "9",

pages = "770--773",

journal = "Brain Stimulation",

issn = "1935-861X",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Anterior Thalamic Deep Brain Stimulation

T2 - Functional Activation Patterns in a Large Animal Model

AU - Gibson, William S.

AU - Ross, Erika K.

AU - Han, Seong Rok

AU - Van Gompel, Jamie J.

AU - Min, Hoon Ki

AU - Lee, Kendall H.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background Deep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) exerts its effects by modulating neural circuits involved in seizures. However, these networks remain incompletely characterized. Objective Investigate the effects of ATN DBS on network activity in a large animal model using 3-T fMRI. Methods Anesthetized swine underwent ATN DBS using stimulation parameters applied in the Stimulation of the Anterior Thalamus for the Treatment of Epilepsy (SANTE) trial. Stimulation amplitude, frequency, and temporal paradigm were varied and the resulting blood oxygen level-dependent signal was measured. Results ATN DBS resulted in activation within temporal, prefrontal, and sensorimotor cortex. An amplitude-dependent increase in cluster volume was observed at 60 Hz and 145 Hz stimulation. Conclusion ATN DBS in swine induced parameter-dependent activation in cortical regions including but not limited to the Papez circuit. These findings may hold clinical implications for treatment of epilepsy in patients with temporal or extratemporal seizure foci.

AB - Background Deep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) exerts its effects by modulating neural circuits involved in seizures. However, these networks remain incompletely characterized. Objective Investigate the effects of ATN DBS on network activity in a large animal model using 3-T fMRI. Methods Anesthetized swine underwent ATN DBS using stimulation parameters applied in the Stimulation of the Anterior Thalamus for the Treatment of Epilepsy (SANTE) trial. Stimulation amplitude, frequency, and temporal paradigm were varied and the resulting blood oxygen level-dependent signal was measured. Results ATN DBS resulted in activation within temporal, prefrontal, and sensorimotor cortex. An amplitude-dependent increase in cluster volume was observed at 60 Hz and 145 Hz stimulation. Conclusion ATN DBS in swine induced parameter-dependent activation in cortical regions including but not limited to the Papez circuit. These findings may hold clinical implications for treatment of epilepsy in patients with temporal or extratemporal seizure foci.

KW - Anterior thalamic nucleus

KW - Deep brain stimulation

KW - Epilepsy

KW - fMRI

UR - http://www.scopus.com/inward/record.url?scp=84964958497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964958497&partnerID=8YFLogxK

U2 - 10.1016/j.brs.2016.04.012

DO - 10.1016/j.brs.2016.04.012

M3 - Article

C2 - 27160467

AN - SCOPUS:84964958497

SN - 1935-861X

VL - 9

SP - 770

EP - 773

JO - Brain Stimulation

JF - Brain Stimulation

IS - 5

ER -

Anterior Thalamic Deep Brain Stimulation: Functional Activation Patterns in a Large Animal Model

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this