Anterior Thalamic Deep Brain Stimulation: Functional Activation Patterns in a Large Animal Model

William S. Gibson, Erika K. Ross, Seong Rok Han, Jamie Van Gompel, Hoon Ki Min, Kendall H Lee

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Deep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) exerts its effects by modulating neural circuits involved in seizures. However, these networks remain incompletely characterized. Objective: Investigate the effects of ATN DBS on network activity in a large animal model using 3-T fMRI. Methods: Anesthetized swine underwent ATN DBS using stimulation parameters applied in the Stimulation of the Anterior Thalamus for the Treatment of Epilepsy (SANTE) trial. Stimulation amplitude, frequency, and temporal paradigm were varied and the resulting blood oxygen level-dependent signal was measured. Results: ATN DBS resulted in activation within temporal, prefrontal, and sensorimotor cortex. An amplitude-dependent increase in cluster volume was observed at 60 Hz and 145 Hz stimulation. Conclusion: ATN DBS in swine induced parameter-dependent activation in cortical regions including but not limited to the Papez circuit. These findings may hold clinical implications for treatment of epilepsy in patients with temporal or extratemporal seizure foci.

Original languageEnglish (US)
JournalBrain Stimulation
DOIs
StateAccepted/In press - Feb 1 2016

Fingerprint

Anterior Thalamic Nuclei
Deep Brain Stimulation
Animal Models
Epilepsy
Seizures
Swine
Temporal Lobe
Prefrontal Cortex
Magnetic Resonance Imaging
Oxygen
Therapeutics

Keywords

  • Anterior thalamic nucleus
  • Deep brain stimulation
  • Epilepsy
  • FMRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Biophysics

Cite this

Anterior Thalamic Deep Brain Stimulation : Functional Activation Patterns in a Large Animal Model. / Gibson, William S.; Ross, Erika K.; Han, Seong Rok; Van Gompel, Jamie; Min, Hoon Ki; Lee, Kendall H.

In: Brain Stimulation, 01.02.2016.

Research output: Contribution to journalArticle

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