Ante mortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies

Kejal M Kantarci, Chunhui Yang, Julie A. Schneider, Matthew L. Senjem, Denise A. Reyes, Val Lowe, Lisa L. Barnes, Neelum T. Aggarwal, David A. Bennett, Glenn E. Smith, Ronald Carl Petersen, Clifford R Jr. Jack, Bradley F Boeve

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The association between ante mortem [ 11C]-Pittsburgh Compound B (PiB) retention and β-amyloid (Aβ) load, Lewy body (LB) and neurofibrillary tangle (NFT) densities were investigated in a pathologically confirmed case of dementia with Lewy bodies (DLB). A 76 year old man presenting with a clinical diagnosis of DLB had undergone PiB-positron emission tomography (PET), 18F FDG-PET and magnetic resonance imaging (MRI) 18 months before death. The pathologic diagnosis was DLB neocortical-type with low-likelihood of Alzheimer's disease by NIA-Reagan criteria. Sections from regions of interest (ROI) on post-mortem examination were studied. A significant correlation was found between cortical Aβ density and PiB retention in the 17 corresponding ROIs (r = 0.899; p < 0.0001). Bielschowsky silver stain revealed mostly sparse neocortical neuritic plaques, whereas diffuse plaques were frequent. There was no correlation between LB density and PiB retention (r = 0.13; p = 0.66); nor between NFT density and PiB retention (r = -0.36; p = 0.17). The ROI-based analysis of imaging and histopathological data confirms that PiB uptake on PET is a specific marker for Aβ density, but cannot differentiate neuritic from diffuse amyloid plaques in this case with DLB.

Original languageEnglish (US)
Pages (from-to)878-885
Number of pages8
JournalNeurobiology of Aging
Volume33
Issue number5
DOIs
StatePublished - May 2012

Fingerprint

Lewy Body Disease
Amyloid
Pathology
Positron-Emission Tomography
Lewy Bodies
Neurofibrillary Tangles
Amyloid Plaques
Somatotypes
Fluorodeoxyglucose F18
Silver
Dementia
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Autopsy
Alzheimer Disease
Coloring Agents
Magnetic Resonance Imaging

Keywords

  • Amyloid
  • Amyloid imaging
  • Dementia with Lewy bodies
  • Pathology
  • PET

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Ante mortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies. / Kantarci, Kejal M; Yang, Chunhui; Schneider, Julie A.; Senjem, Matthew L.; Reyes, Denise A.; Lowe, Val; Barnes, Lisa L.; Aggarwal, Neelum T.; Bennett, David A.; Smith, Glenn E.; Petersen, Ronald Carl; Jack, Clifford R Jr.; Boeve, Bradley F.

In: Neurobiology of Aging, Vol. 33, No. 5, 05.2012, p. 878-885.

Research output: Contribution to journalArticle

Kantarci, Kejal M ; Yang, Chunhui ; Schneider, Julie A. ; Senjem, Matthew L. ; Reyes, Denise A. ; Lowe, Val ; Barnes, Lisa L. ; Aggarwal, Neelum T. ; Bennett, David A. ; Smith, Glenn E. ; Petersen, Ronald Carl ; Jack, Clifford R Jr. ; Boeve, Bradley F. / Ante mortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies. In: Neurobiology of Aging. 2012 ; Vol. 33, No. 5. pp. 878-885.
@article{c154a352f4c54febb50cf4259ab3e911,
title = "Ante mortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies",
abstract = "The association between ante mortem [ 11C]-Pittsburgh Compound B (PiB) retention and β-amyloid (Aβ) load, Lewy body (LB) and neurofibrillary tangle (NFT) densities were investigated in a pathologically confirmed case of dementia with Lewy bodies (DLB). A 76 year old man presenting with a clinical diagnosis of DLB had undergone PiB-positron emission tomography (PET), 18F FDG-PET and magnetic resonance imaging (MRI) 18 months before death. The pathologic diagnosis was DLB neocortical-type with low-likelihood of Alzheimer's disease by NIA-Reagan criteria. Sections from regions of interest (ROI) on post-mortem examination were studied. A significant correlation was found between cortical Aβ density and PiB retention in the 17 corresponding ROIs (r = 0.899; p < 0.0001). Bielschowsky silver stain revealed mostly sparse neocortical neuritic plaques, whereas diffuse plaques were frequent. There was no correlation between LB density and PiB retention (r = 0.13; p = 0.66); nor between NFT density and PiB retention (r = -0.36; p = 0.17). The ROI-based analysis of imaging and histopathological data confirms that PiB uptake on PET is a specific marker for Aβ density, but cannot differentiate neuritic from diffuse amyloid plaques in this case with DLB.",
keywords = "Amyloid, Amyloid imaging, Dementia with Lewy bodies, Pathology, PET",
author = "Kantarci, {Kejal M} and Chunhui Yang and Schneider, {Julie A.} and Senjem, {Matthew L.} and Reyes, {Denise A.} and Val Lowe and Barnes, {Lisa L.} and Aggarwal, {Neelum T.} and Bennett, {David A.} and Smith, {Glenn E.} and Petersen, {Ronald Carl} and Jack, {Clifford R Jr.} and Boeve, {Bradley F}",
year = "2012",
month = "5",
doi = "10.1016/j.neurobiolaging.2010.08.007",
language = "English (US)",
volume = "33",
pages = "878--885",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Ante mortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies

AU - Kantarci, Kejal M

AU - Yang, Chunhui

AU - Schneider, Julie A.

AU - Senjem, Matthew L.

AU - Reyes, Denise A.

AU - Lowe, Val

AU - Barnes, Lisa L.

AU - Aggarwal, Neelum T.

AU - Bennett, David A.

AU - Smith, Glenn E.

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

AU - Boeve, Bradley F

PY - 2012/5

Y1 - 2012/5

N2 - The association between ante mortem [ 11C]-Pittsburgh Compound B (PiB) retention and β-amyloid (Aβ) load, Lewy body (LB) and neurofibrillary tangle (NFT) densities were investigated in a pathologically confirmed case of dementia with Lewy bodies (DLB). A 76 year old man presenting with a clinical diagnosis of DLB had undergone PiB-positron emission tomography (PET), 18F FDG-PET and magnetic resonance imaging (MRI) 18 months before death. The pathologic diagnosis was DLB neocortical-type with low-likelihood of Alzheimer's disease by NIA-Reagan criteria. Sections from regions of interest (ROI) on post-mortem examination were studied. A significant correlation was found between cortical Aβ density and PiB retention in the 17 corresponding ROIs (r = 0.899; p < 0.0001). Bielschowsky silver stain revealed mostly sparse neocortical neuritic plaques, whereas diffuse plaques were frequent. There was no correlation between LB density and PiB retention (r = 0.13; p = 0.66); nor between NFT density and PiB retention (r = -0.36; p = 0.17). The ROI-based analysis of imaging and histopathological data confirms that PiB uptake on PET is a specific marker for Aβ density, but cannot differentiate neuritic from diffuse amyloid plaques in this case with DLB.

AB - The association between ante mortem [ 11C]-Pittsburgh Compound B (PiB) retention and β-amyloid (Aβ) load, Lewy body (LB) and neurofibrillary tangle (NFT) densities were investigated in a pathologically confirmed case of dementia with Lewy bodies (DLB). A 76 year old man presenting with a clinical diagnosis of DLB had undergone PiB-positron emission tomography (PET), 18F FDG-PET and magnetic resonance imaging (MRI) 18 months before death. The pathologic diagnosis was DLB neocortical-type with low-likelihood of Alzheimer's disease by NIA-Reagan criteria. Sections from regions of interest (ROI) on post-mortem examination were studied. A significant correlation was found between cortical Aβ density and PiB retention in the 17 corresponding ROIs (r = 0.899; p < 0.0001). Bielschowsky silver stain revealed mostly sparse neocortical neuritic plaques, whereas diffuse plaques were frequent. There was no correlation between LB density and PiB retention (r = 0.13; p = 0.66); nor between NFT density and PiB retention (r = -0.36; p = 0.17). The ROI-based analysis of imaging and histopathological data confirms that PiB uptake on PET is a specific marker for Aβ density, but cannot differentiate neuritic from diffuse amyloid plaques in this case with DLB.

KW - Amyloid

KW - Amyloid imaging

KW - Dementia with Lewy bodies

KW - Pathology

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=84858336551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858336551&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2010.08.007

DO - 10.1016/j.neurobiolaging.2010.08.007

M3 - Article

VL - 33

SP - 878

EP - 885

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 5

ER -