Ante mortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies

Kejal Kantarci, Chunhui Yang, Julie A. Schneider, Matthew L. Senjem, Denise A. Reyes, Val J. Lowe, Lisa L. Barnes, Neelum T. Aggarwal, David A. Bennett, Glenn E. Smith, Ronald C. Petersen, Clifford R. Jack, Bradley F. Boeve

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

The association between ante mortem [ 11C]-Pittsburgh Compound B (PiB) retention and β-amyloid (Aβ) load, Lewy body (LB) and neurofibrillary tangle (NFT) densities were investigated in a pathologically confirmed case of dementia with Lewy bodies (DLB). A 76 year old man presenting with a clinical diagnosis of DLB had undergone PiB-positron emission tomography (PET), 18F FDG-PET and magnetic resonance imaging (MRI) 18 months before death. The pathologic diagnosis was DLB neocortical-type with low-likelihood of Alzheimer's disease by NIA-Reagan criteria. Sections from regions of interest (ROI) on post-mortem examination were studied. A significant correlation was found between cortical Aβ density and PiB retention in the 17 corresponding ROIs (r = 0.899; p < 0.0001). Bielschowsky silver stain revealed mostly sparse neocortical neuritic plaques, whereas diffuse plaques were frequent. There was no correlation between LB density and PiB retention (r = 0.13; p = 0.66); nor between NFT density and PiB retention (r = -0.36; p = 0.17). The ROI-based analysis of imaging and histopathological data confirms that PiB uptake on PET is a specific marker for Aβ density, but cannot differentiate neuritic from diffuse amyloid plaques in this case with DLB.

Original languageEnglish (US)
Pages (from-to)878-885
Number of pages8
JournalNeurobiology of aging
Volume33
Issue number5
DOIs
StatePublished - May 1 2012

Keywords

  • Amyloid
  • Amyloid imaging
  • Dementia with Lewy bodies
  • PET
  • Pathology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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