Using radioligand binding techniques and human frontal cortex, we determined the equilibrium dissociation constants (KDS ) of 17 neuroleptics at the serotonin 5-HT1A and serotonin 5-HT2 receptors with [3H]WB4101 and [3H]ketanserin, respectively. At the serotonin 5-HT1A receptor, the most and least potent neuroleptics were chlorprothixene (KD = 230 nM) and fluphenazine (KD = 40 μM), respectively. At the serotonin 5-HT2 receptor, the most and least potent neuroleptics were spiperone (KD = 0.38 nM)and molindone, (KD = 5 μM), respectively.
- Serotonin receptors
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience