Antagonism between Camptothecin and Topoisomerase II-directed Chemotherapeutic Agents in a Human Leukemia Cell Line

Medicine & Life Sciences

• Camptothecin 100%
• Type II DNA Topoisomerase 99%
• Leukemia 62%
• Etoposide 61%
• Cell Line 45%
• HL-60 Cells 33%
• 3-chloro-4,4-dimethyl-2-oxazolidinone 17%
• cordycepin 15%
• Aphidicolin 14%
• Topotecan 13%
• Type I DNA Topoisomerase 12%
• Daunorubicin 12%
• Acute Promyelocytic Leukemia 11%
• DNA Adducts 11%
• DNA Breaks 11%
• Clinical Trials, Phase I 11%
• Agar 9%
• RNA 6%
• Western Blotting 6%
• Survival 5%
• Therapeutics 3%