Anomalies Characteristic of Central Nervous System Demyelination: Radiologically Isolated Syndrome

RISConsortium

doi:10.1016/j.ncl.2017.08.004

Anomalies Characteristic of Central Nervous System Demyelination: Radiologically Isolated Syndrome

RISConsortium

Neurology

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Radiologically isolated syndrome (RIS) was defined in 2009 for asymptomatic patients who presented incidentally identified white matter anomalies within the central nervous system suggestive of multiple sclerosis (MS). Approximately one-third of RIS subjects will have a seminal clinical demyelinating event within 5 years of the identification of their abnormal MRI. Clinical evolution mirrors relapsing remitting or progressive forms of MS. Pejorative factors for clinical conversion are male gender, age younger than 35 years, and spinal cord lesions.

Original language	English (US)
Pages (from-to)	59-68
Number of pages	10
Journal	Neurologic clinics
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.ncl.2017.08.004
State	Published - Feb 2018

Keywords

Clinically isolated syndrome
Incidental findings
MRI
Multiple sclerosis
Radiologically isolated syndrome

ASJC Scopus subject areas

Clinical Neurology

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10.1016/j.ncl.2017.08.004

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title = "Anomalies Characteristic of Central Nervous System Demyelination: Radiologically Isolated Syndrome",

abstract = "Radiologically isolated syndrome (RIS) was defined in 2009 for asymptomatic patients who presented incidentally identified white matter anomalies within the central nervous system suggestive of multiple sclerosis (MS). Approximately one-third of RIS subjects will have a seminal clinical demyelinating event within 5 years of the identification of their abnormal MRI. Clinical evolution mirrors relapsing remitting or progressive forms of MS. Pejorative factors for clinical conversion are male gender, age younger than 35 years, and spinal cord lesions.",

keywords = "Clinically isolated syndrome, Incidental findings, MRI, Multiple sclerosis, Radiologically isolated syndrome",

author = "RISConsortium and Christine Lebrun and Kantarci, {Orhun H.} and Aksel Siva and Daniel Pelletier and Okuda, {Darin T.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2018",

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doi = "10.1016/j.ncl.2017.08.004",

language = "English (US)",

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T1 - Anomalies Characteristic of Central Nervous System Demyelination

T2 - Radiologically Isolated Syndrome

AU - RISConsortium

AU - Lebrun, Christine

AU - Kantarci, Orhun H.

AU - Siva, Aksel

AU - Pelletier, Daniel

AU - Okuda, Darin T.

PY - 2018/2

Y1 - 2018/2

N2 - Radiologically isolated syndrome (RIS) was defined in 2009 for asymptomatic patients who presented incidentally identified white matter anomalies within the central nervous system suggestive of multiple sclerosis (MS). Approximately one-third of RIS subjects will have a seminal clinical demyelinating event within 5 years of the identification of their abnormal MRI. Clinical evolution mirrors relapsing remitting or progressive forms of MS. Pejorative factors for clinical conversion are male gender, age younger than 35 years, and spinal cord lesions.

AB - Radiologically isolated syndrome (RIS) was defined in 2009 for asymptomatic patients who presented incidentally identified white matter anomalies within the central nervous system suggestive of multiple sclerosis (MS). Approximately one-third of RIS subjects will have a seminal clinical demyelinating event within 5 years of the identification of their abnormal MRI. Clinical evolution mirrors relapsing remitting or progressive forms of MS. Pejorative factors for clinical conversion are male gender, age younger than 35 years, and spinal cord lesions.

KW - Clinically isolated syndrome

KW - Incidental findings

KW - MRI

KW - Multiple sclerosis

KW - Radiologically isolated syndrome

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JO - Neurologic clinics

JF - Neurologic clinics

IS - 1

ER -

Anomalies Characteristic of Central Nervous System Demyelination: Radiologically Isolated Syndrome

Abstract

Keywords

ASJC Scopus subject areas

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