Animal models of venous thrombosis

Hassan Albadawi, Avery A. Witting, Yash Pershad, Alex Wallace, Andrew R. Fleck, Peter Hoang, Ali Khademhosseini, Rahmi Oklu

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Venous thrombosis (VT) is a prevalent clinical condition with significant adverse sequela or mortality. Anticoagulation and pharmacologic or pharmacomechanical thrombolytic therapies are the mainstays of VT treatment. An understanding of thrombosis biology will allow for more effective VT-tailored diagnosis and therapy. In vivo models of thrombosis provide indispensable tools to study the pathogenesis of thrombus formation and to evaluate novel therapeutic or preventive adjuncts for VT management or prevention. In this article, we review the most prominent in vivo models of VT created in rodents and swine species and outline how each model can serve as a useful tool to promote our understanding of VT pathogenesis and to examine novel therapies.

Original languageEnglish (US)
Pages (from-to)S197-S206
JournalCardiovascular Diagnosis and Therapy
Volume7
DOIs
StatePublished - Dec 1 2017

Keywords

  • Blood coagulation
  • Experimental animal models
  • Thrombolytic therapy
  • Thrombosis
  • Veins
  • Venous thrombosis (VT)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Albadawi, H., Witting, A. A., Pershad, Y., Wallace, A., Fleck, A. R., Hoang, P., Khademhosseini, A., & Oklu, R. (2017). Animal models of venous thrombosis. Cardiovascular Diagnosis and Therapy, 7, S197-S206. https://doi.org/10.21037/cdt.2017.08.10