Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies

R. Talac, J. A. Friedman, M. J. Moore, Lichun Lu, E. Jabbari, Anthony John Windebank, B. L. Currier, Michael J Yaszemski

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Tissue engineering approaches to spinal cord injury (SCI) treatment are attractive because they allow for manipulation of native regeneration processes involved in restoration of the integrity and function of damaged tissue. A clinically relevant spinal cord regeneration animal model requires that the model mimics specific pathologic processes that occur in human SCI. This manuscript discusses issues related to preclinical testing of tissue engineering spinal cord regeneration strategies from a number of perspectives. This discussion includes diverse causes, pathology and functional consequences of human SCI, general and species related considerations, technical and animal care considerations, and data analysis methods.

Original languageEnglish (US)
Pages (from-to)1505-1510
Number of pages6
JournalBiomaterials
Volume25
Issue number9
DOIs
StatePublished - Apr 2004

Fingerprint

Tissue Engineering
Spinal Cord Injuries
Spinal Cord Regeneration
Tissue engineering
Animals
Animal Models
Pathologic Processes
Regeneration
Pathology
Restoration
Tissue
Testing

Keywords

  • Animal models
  • Spinal cord injury
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies. / Talac, R.; Friedman, J. A.; Moore, M. J.; Lu, Lichun; Jabbari, E.; Windebank, Anthony John; Currier, B. L.; Yaszemski, Michael J.

In: Biomaterials, Vol. 25, No. 9, 04.2004, p. 1505-1510.

Research output: Contribution to journalArticle

Talac, R. ; Friedman, J. A. ; Moore, M. J. ; Lu, Lichun ; Jabbari, E. ; Windebank, Anthony John ; Currier, B. L. ; Yaszemski, Michael J. / Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies. In: Biomaterials. 2004 ; Vol. 25, No. 9. pp. 1505-1510.
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