Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies

R. Talac, J. A. Friedman, M. J. Moore, L. Lu, E. Jabbari, A. J. Windebank, B. L. Currier, M. J. Yaszemski

Research output: Contribution to journalArticle

83 Scopus citations


Tissue engineering approaches to spinal cord injury (SCI) treatment are attractive because they allow for manipulation of native regeneration processes involved in restoration of the integrity and function of damaged tissue. A clinically relevant spinal cord regeneration animal model requires that the model mimics specific pathologic processes that occur in human SCI. This manuscript discusses issues related to preclinical testing of tissue engineering spinal cord regeneration strategies from a number of perspectives. This discussion includes diverse causes, pathology and functional consequences of human SCI, general and species related considerations, technical and animal care considerations, and data analysis methods.

Original languageEnglish (US)
Pages (from-to)1505-1510
Number of pages6
Issue number9
StatePublished - Apr 2004



  • Animal models
  • Spinal cord injury
  • Tissue engineering

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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