Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies

R. Talac; J. A. Friedman; M. J. Moore; L. Lu; E. Jabbari; A. J. Windebank; B. L. Currier; M. J. Yaszemski

doi:10.1016/S0142-9612(03)00497-6

Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies

R. Talac, J. A. Friedman, M. J. Moore, L. Lu, E. Jabbari, A. J. Windebank, B. L. Currier, M. J. Yaszemski

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92 Scopus citations

Abstract

Tissue engineering approaches to spinal cord injury (SCI) treatment are attractive because they allow for manipulation of native regeneration processes involved in restoration of the integrity and function of damaged tissue. A clinically relevant spinal cord regeneration animal model requires that the model mimics specific pathologic processes that occur in human SCI. This manuscript discusses issues related to preclinical testing of tissue engineering spinal cord regeneration strategies from a number of perspectives. This discussion includes diverse causes, pathology and functional consequences of human SCI, general and species related considerations, technical and animal care considerations, and data analysis methods.

Original language	English (US)
Pages (from-to)	1505-1510
Number of pages	6
Journal	Biomaterials
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/S0142-9612(03)00497-6
State	Published - Apr 2004

Keywords

Animal models
Spinal cord injury
Tissue engineering

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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AU - Talac, R.

AU - Friedman, J. A.

AU - Moore, M. J.

AU - Lu, L.

AU - Jabbari, E.

AU - Windebank, A. J.

AU - Currier, B. L.

AU - Yaszemski, M. J.

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AB - Tissue engineering approaches to spinal cord injury (SCI) treatment are attractive because they allow for manipulation of native regeneration processes involved in restoration of the integrity and function of damaged tissue. A clinically relevant spinal cord regeneration animal model requires that the model mimics specific pathologic processes that occur in human SCI. This manuscript discusses issues related to preclinical testing of tissue engineering spinal cord regeneration strategies from a number of perspectives. This discussion includes diverse causes, pathology and functional consequences of human SCI, general and species related considerations, technical and animal care considerations, and data analysis methods.

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KW - Spinal cord injury

KW - Tissue engineering

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Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies

Abstract

Keywords

ASJC Scopus subject areas

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