Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame

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67 Citations (Scopus)

Abstract

With the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become a public health problem with increasing prevalence. The mechanism of disease progression remains obscure and effective therapy is lacking. Therefore, there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies. To accomplish this goal, experimental animal models that recapitulate the human disease are necessary, especially, since causative mechanistic studies of NAFLD are more difficult or unethical to perform in humans. A large number of studies regarding the pathophysiology and treatment of nonalcoholic steatohepatitis (NASH) have been undertaken in mice to model human NAFLD and NASH. This review discusses the known dietary, genetic, and inflammation-based animal models of NASH described in recent years, with a focus on the major advances made in this field.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalDigestive Diseases and Sciences
DOIs
StateAccepted/In press - Dec 1 2015

Fingerprint

Animal Models
Disease Progression
Investigational Therapies
Non-alcoholic Fatty Liver Disease
Public Health
Obesity
Inflammation
Therapeutics

Keywords

  • Animal model
  • Fibrosis
  • Hepatocellular ballooning
  • Inflammation
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • Steatosis

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

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title = "Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame",
abstract = "With the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become a public health problem with increasing prevalence. The mechanism of disease progression remains obscure and effective therapy is lacking. Therefore, there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies. To accomplish this goal, experimental animal models that recapitulate the human disease are necessary, especially, since causative mechanistic studies of NAFLD are more difficult or unethical to perform in humans. A large number of studies regarding the pathophysiology and treatment of nonalcoholic steatohepatitis (NASH) have been undertaken in mice to model human NAFLD and NASH. This review discusses the known dietary, genetic, and inflammation-based animal models of NASH described in recent years, with a focus on the major advances made in this field.",
keywords = "Animal model, Fibrosis, Hepatocellular ballooning, Inflammation, Nonalcoholic fatty liver disease, Nonalcoholic steatohepatitis, Steatosis",
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AU - Hirsova, Petra

AU - Malhi, Harmeet M

AU - Gores, Gregory James

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N2 - With the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become a public health problem with increasing prevalence. The mechanism of disease progression remains obscure and effective therapy is lacking. Therefore, there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies. To accomplish this goal, experimental animal models that recapitulate the human disease are necessary, especially, since causative mechanistic studies of NAFLD are more difficult or unethical to perform in humans. A large number of studies regarding the pathophysiology and treatment of nonalcoholic steatohepatitis (NASH) have been undertaken in mice to model human NAFLD and NASH. This review discusses the known dietary, genetic, and inflammation-based animal models of NASH described in recent years, with a focus on the major advances made in this field.

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