Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis

Xianbao Zhan, Fan Wang, Yan Bi, Baoan Ji

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Animal models of pancreatitis are useful for elucidating the pathogenesis of pancreatitis and developing and testing novel interventions. In this review, we aim to summarize the most commonly used animal models, overview their pathophysiology, and discuss their strengths and limitations. We will also briefly describe common animal study procedures and refer readers to more detailed protocols in the literature. Although animal models include pigs, dogs, opossums, and other animals, we will mainly focus on rodent models because of their popularity. Autoimmune pancreatitis and genetically engineered animal models will be reviewed elsewhere.

Original languageEnglish (US)
Pages (from-to)G343-G355
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume311
Issue number3
DOIs
StatePublished - 2016

Keywords

  • Fibrosis
  • Inflammation
  • Pancreatic disorder

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

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