Animal models of fibrodysplasia ossificans progressiva

Frederick S. Kaplan; Eileen M. Shore; Robert J. Pignolo; David L. Glaser

doi:10.1385/BMM:3:3-4:229

Animal models of fibrodysplasia ossificans progressiva

Frederick S. Kaplan, Eileen M. Shore, Robert J. Pignolo, David L. Glaser

Hospital Internal Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Animal models of fibrodysplasia ossificans progressiva (FOP) are important for understanding the pathophysiology of FOP and for testing possible therapies. Laboratory-generated genetic animal models, each with features of FOP, provide the opportunity to better understand the biology of FOP, and to study the effectiveness and safety of currently available and emerging therapies.

Original language	English (US)
Pages (from-to)	229-234
Number of pages	6
Journal	Clinical Reviews in Bone and Mineral Metabolism
Volume	3
Issue number	3-4
DOIs	https://doi.org/10.1385/BMM:3:3-4:229
State	Published - Sep 2005

Keywords

Animal models
BMP4
Fibrodysplasia ossificans progressiva (FOP)
Heterotopic ossification

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
Endocrinology

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10.1385/BMM:3:3-4:229

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title = "Animal models of fibrodysplasia ossificans progressiva",

abstract = "Animal models of fibrodysplasia ossificans progressiva (FOP) are important for understanding the pathophysiology of FOP and for testing possible therapies. Laboratory-generated genetic animal models, each with features of FOP, provide the opportunity to better understand the biology of FOP, and to study the effectiveness and safety of currently available and emerging therapies.",

keywords = "Animal models, BMP4, Fibrodysplasia ossificans progressiva (FOP), Heterotopic ossification",

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AU - Kaplan, Frederick S.

AU - Shore, Eileen M.

AU - Pignolo, Robert J.

AU - Glaser, David L.

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N2 - Animal models of fibrodysplasia ossificans progressiva (FOP) are important for understanding the pathophysiology of FOP and for testing possible therapies. Laboratory-generated genetic animal models, each with features of FOP, provide the opportunity to better understand the biology of FOP, and to study the effectiveness and safety of currently available and emerging therapies.

AB - Animal models of fibrodysplasia ossificans progressiva (FOP) are important for understanding the pathophysiology of FOP and for testing possible therapies. Laboratory-generated genetic animal models, each with features of FOP, provide the opportunity to better understand the biology of FOP, and to study the effectiveness and safety of currently available and emerging therapies.

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KW - BMP4

KW - Fibrodysplasia ossificans progressiva (FOP)

KW - Heterotopic ossification

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ER -

Animal models of fibrodysplasia ossificans progressiva

Abstract

Keywords

ASJC Scopus subject areas

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