Animal models of cholangiocarcinoma

Emilien Loeuillard, Samantha R. Fischbach, Gregory James Gores, Sumera Rizvi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with a poor overall prognosis. There is a critical need to develop effective targeted therapies for the treatment of this lethal disease. In an effort to address this challenge, preclinical in vivo studies have become paramount in understanding CCA carcinogenesis, progression, and therapy. Various CCA animal models exist including carcinogen-based models in which animals develop CCA after exposure to a carcinogen, genetically engineered mouse models in which genetic changes are induced in mice leading to CCA, murine syngeneic orthotopic models, as well as xenograft tumors derived from xenotransplantation of CCA cells, organoids, and patient-derived tissue. Each type has distinct advantages as well as shortcomings. In the ideal animal model of CCA, the tumor arises from the biliary tract in an immunocompetent host with a species-matched tumor microenvironment. Such a model would also be time-efficient, recapitulate the genetic and histopathological features of human CCA, and predict therapeutic response in humans. Recently developed biliary tract transduction and orthotopic syngeneic transplant mouse models encompass several of these elements. Herein, we review the different animal models of CCA, their advantages and deficiencies, as well as features which mimic human CCA.

Original languageEnglish (US)
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
DOIs
StateAccepted/In press - Jan 1 2018

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Cholangiocarcinoma
Animal Models
Biliary Tract
Carcinogens
Organoids
Neoplasms
Heterologous Transplantation
Tumor Microenvironment
Therapeutics
Heterografts
Carcinogenesis
Transplants

Keywords

  • Orthotopic
  • Transduction
  • Transgenic
  • Xenotransplantation

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Animal models of cholangiocarcinoma. / Loeuillard, Emilien; Fischbach, Samantha R.; Gores, Gregory James; Rizvi, Sumera.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, 01.01.2018.

Research output: Contribution to journalArticle

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