Abstract
Currently no 'true' animal models of celiac disease exist in which all of the elements unique to celiac disease are present. HLA transgenic mice show promise, since these mice have served as good models for other autoimmune diseases, such as diabetes, asthma, arthritis and multiple sclerosis. HLA-DQ8 transgenic mice have been shown to be gluten sensitive and, when placed onto a genetic background that is predisposed to autoimmunity, will develop dermatitis herpetiformis, which is the skin manifestation of celiac disease. Thus, HLA transgenic mice may be valuable in understanding the pathogenesis of celiac disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 210-216 |
| Number of pages | 7 |
| Journal | Pediatric and Adolescent Medicine |
| Volume | 12 |
| DOIs | |
| State | Published - 2008 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Animal models of celiac disease. / Marietta, Eric V.; Murray, Joseph A; David, Chella S.
In: Pediatric and Adolescent Medicine, Vol. 12, 2008, p. 210-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Animal models of celiac disease
AU - Marietta, Eric V.
AU - Murray, Joseph A
AU - David, Chella S.
PY - 2008
Y1 - 2008
N2 - Currently no 'true' animal models of celiac disease exist in which all of the elements unique to celiac disease are present. HLA transgenic mice show promise, since these mice have served as good models for other autoimmune diseases, such as diabetes, asthma, arthritis and multiple sclerosis. HLA-DQ8 transgenic mice have been shown to be gluten sensitive and, when placed onto a genetic background that is predisposed to autoimmunity, will develop dermatitis herpetiformis, which is the skin manifestation of celiac disease. Thus, HLA transgenic mice may be valuable in understanding the pathogenesis of celiac disease.
AB - Currently no 'true' animal models of celiac disease exist in which all of the elements unique to celiac disease are present. HLA transgenic mice show promise, since these mice have served as good models for other autoimmune diseases, such as diabetes, asthma, arthritis and multiple sclerosis. HLA-DQ8 transgenic mice have been shown to be gluten sensitive and, when placed onto a genetic background that is predisposed to autoimmunity, will develop dermatitis herpetiformis, which is the skin manifestation of celiac disease. Thus, HLA transgenic mice may be valuable in understanding the pathogenesis of celiac disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=84870187451&partnerID=8YFLogxK
U2 - 10.1159/000129070
DO - 10.1159/000129070
M3 - Article
VL - 12
SP - 210
EP - 216
JO - Pediatric and Adolescent Medicine
JF - Pediatric and Adolescent Medicine
SN - 1017-5989
ER -