Animal models of celiac disease

Eric V. Marietta, Joseph A. Murray, Chella S. David

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Currently no 'true' animal models of celiac disease exist in which all of the elements unique to celiac disease are present. HLA transgenic mice show promise, since these mice have served as good models for other autoimmune diseases, such as diabetes, asthma, arthritis and multiple sclerosis. HLA-DQ8 transgenic mice have been shown to be gluten sensitive and, when placed onto a genetic background that is predisposed to autoimmunity, will develop dermatitis herpetiformis, which is the skin manifestation of celiac disease. Thus, HLA transgenic mice may be valuable in understanding the pathogenesis of celiac disease.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalPediatric and Adolescent Medicine
Volume12
DOIs
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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