ANIMAL MODELS FOR PREDICTING CLINICAL PERFORMANCE OF BIOMATERIALS FOR CARDIOVASCULAR USE.

Paul Didisheim; Mrinal K. Dewanjee; Craig S. Frisk; Michael P. Kaye; David N. Fass

ANIMAL MODELS FOR PREDICTING CLINICAL PERFORMANCE OF BIOMATERIALS FOR CARDIOVASCULAR USE.

Paul Didisheim, Mrinal K. Dewanjee, Craig S. Frisk, Michael P. Kaye, David N. Fass

Comparative Medicine (Veterinary Medicine)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

14 Scopus citations

Abstract

The major problems encountered with prosthetic biomaterials in contact with blood are thrombosis, embolism, pseudointimal proliferation, calcification, and mechanical failure and functional abnormalities of blood cells. In this paper methods are described for the preclinical evaluation of blood-material interactions. These methods include animal models. A correlation is found between the nature of the cellular response to three biomaterials (Gore-Tex, Woven Dacron, and Teflon Felt) and the results of several in vitro and ex vivo tests.

Original language	English (US)
Title of host publication	Contemp Biomater, Mater and Host Response, Clin Appl, New Technol and Leg Aspects
Publisher	Noyes Publ
Pages	132-179
Number of pages	48
ISBN (Print)	0815509804
State	Published - Dec 1 1984

ASJC Scopus subject areas

Engineering(all)

Cite this

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abstract = "The major problems encountered with prosthetic biomaterials in contact with blood are thrombosis, embolism, pseudointimal proliferation, calcification, and mechanical failure and functional abnormalities of blood cells. In this paper methods are described for the preclinical evaluation of blood-material interactions. These methods include animal models. A correlation is found between the nature of the cellular response to three biomaterials (Gore-Tex, Woven Dacron, and Teflon Felt) and the results of several in vitro and ex vivo tests.",

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AU - Didisheim, Paul

AU - Dewanjee, Mrinal K.

AU - Frisk, Craig S.

AU - Kaye, Michael P.

AU - Fass, David N.

PY - 1984/12/1

Y1 - 1984/12/1

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AB - The major problems encountered with prosthetic biomaterials in contact with blood are thrombosis, embolism, pseudointimal proliferation, calcification, and mechanical failure and functional abnormalities of blood cells. In this paper methods are described for the preclinical evaluation of blood-material interactions. These methods include animal models. A correlation is found between the nature of the cellular response to three biomaterials (Gore-Tex, Woven Dacron, and Teflon Felt) and the results of several in vitro and ex vivo tests.

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M3 - Chapter

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PB - Noyes Publ

ER -

ANIMAL MODELS FOR PREDICTING CLINICAL PERFORMANCE OF BIOMATERIALS FOR CARDIOVASCULAR USE.

Abstract

ASJC Scopus subject areas

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