The major problems encountered with prosthetic biomaterials in contact with blood are thrombosis, embolism, pseudointimal proliferation, calcification, and mechanical failure and functional abnormalities of blood cells. In this paper methods are described for the preclinical evaluation of blood-material interactions. These methods include animal models. A correlation is found between the nature of the cellular response to three biomaterials (Gore-Tex, Woven Dacron, and Teflon Felt) and the results of several in vitro and ex vivo tests.
|Original language||English (US)|
|Title of host publication||Contemp Biomater, Mater and Host Response, Clin Appl, New Technol and Leg Aspects|
|Number of pages||48|
|State||Published - Dec 1 1984|
ASJC Scopus subject areas