ANIMAL MODELS FOR PREDICTING CLINICAL PERFORMANCE OF BIOMATERIALS FOR CARDIOVASCULAR USE.

Paul Didisheim, Mrinal K. Dewanjee, Craig S. Frisk, Michael P. Kaye, David N. Fass

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

The major problems encountered with prosthetic biomaterials in contact with blood are thrombosis, embolism, pseudointimal proliferation, calcification, and mechanical failure and functional abnormalities of blood cells. In this paper methods are described for the preclinical evaluation of blood-material interactions. These methods include animal models. A correlation is found between the nature of the cellular response to three biomaterials (Gore-Tex, Woven Dacron, and Teflon Felt) and the results of several in vitro and ex vivo tests.

Original languageEnglish (US)
Title of host publicationContemp Biomater, Mater and Host Response, Clin Appl, New Technol and Leg Aspects
PublisherNoyes Publ
Pages132-179
Number of pages48
ISBN (Print)0815509804
StatePublished - Dec 1 1984

ASJC Scopus subject areas

  • Engineering(all)

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    Didisheim, P., Dewanjee, M. K., Frisk, C. S., Kaye, M. P., & Fass, D. N. (1984). ANIMAL MODELS FOR PREDICTING CLINICAL PERFORMANCE OF BIOMATERIALS FOR CARDIOVASCULAR USE. In Contemp Biomater, Mater and Host Response, Clin Appl, New Technol and Leg Aspects (pp. 132-179). Noyes Publ.