TY - JOUR
T1 - Anidulafungin treatment of candidal central nervous system infection in a murine model
AU - Kang, Cheol In
AU - Rouse, Mark S.
AU - Mandrekar, Jayawant N.
AU - Steckelberg, James M.
AU - Patel, Robin
PY - 2009/8
Y1 - 2009/8
N2 - We established a murine model of Candida albicans central nervous system (CNS) infection and evaluated the efficacy of anidulafungin. Ten milligrams/kg/day anidulafungin, amphotericin B, or voriconazole signifi-cantly reduced mortality and fungal burden in brain tissue, although amphotericin B and 10 mg/kg/day anidulafungin reduced fungal burden in brain tissue to a greater extent than did voriconazole. This suggests a potential role for anidulafungin in the treatment of candidal CNS infection.
AB - We established a murine model of Candida albicans central nervous system (CNS) infection and evaluated the efficacy of anidulafungin. Ten milligrams/kg/day anidulafungin, amphotericin B, or voriconazole signifi-cantly reduced mortality and fungal burden in brain tissue, although amphotericin B and 10 mg/kg/day anidulafungin reduced fungal burden in brain tissue to a greater extent than did voriconazole. This suggests a potential role for anidulafungin in the treatment of candidal CNS infection.
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U2 - 10.1128/AAC.00646-09
DO - 10.1128/AAC.00646-09
M3 - Article
C2 - 19506064
AN - SCOPUS:67749084491
SN - 0066-4804
VL - 53
SP - 3576
EP - 3578
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 8
ER -