Anidulafungin treatment of candidal central nervous system infection in a murine model

Cheol In Kang, Mark S. Rouse, Jayawant N. Mandrekar, James M. Steckelberg, Robin Patel

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We established a murine model of Candida albicans central nervous system (CNS) infection and evaluated the efficacy of anidulafungin. Ten milligrams/kg/day anidulafungin, amphotericin B, or voriconazole signifi-cantly reduced mortality and fungal burden in brain tissue, although amphotericin B and 10 mg/kg/day anidulafungin reduced fungal burden in brain tissue to a greater extent than did voriconazole. This suggests a potential role for anidulafungin in the treatment of candidal CNS infection.

Original languageEnglish (US)
Pages (from-to)3576-3578
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number8
DOIs
StatePublished - Aug 2009

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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