Angiographic correlates of lesion relevance and suitability for percutaneous transluminal coronary angioplasty and coronary artery bypass grafting in the Bypass Angioplasty Revascularization Investigation study (BARI)

Javier Botas, Michael L. Stadius, Martial G. Bourassa, Allan D. Rosen, Hartzell V Schaff, George Sopko, David O. Williams, Alex McMillan, Edwin L. Alderman

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The Bypass Angioplasty Revascularization Investigation (BARI) randomized 1,829 patients to percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass grafting (CABG). Clinical site angiographers categorized lesions of ≥50% diameter stenosis (n = 4,977) as clinically significant (86.4%) or nonsignificant (13.6%), and as favorable or nonfavorable for PTCA or CABG. More lesions were considered favorable for revascularization by CABG than by PTCA (91.5% vs 78.4%; p <0.001), particularly in the subgroup of 99% to 100% lesions (77.6% for CABG vs 21.9% for PTCA; p <0.001). Lesion features, characterized by the BARI core laboratory, were correlated with clinical site angiographers' assessment of clinical importance and suitability for PTCA or CABG. By multivariate analysis, positive predictors of clinical importance for 50% to 95% stenoses were greater stenosis severity, more jeopardized myocardium, larger reference diameter, and proximal vessel location. For 99% to 100% occlusions, predictors were shorter duration of occlusion and more jeopardized myocardium. PTCA suitability for 50% to 95% stenoses was inversely related to lesion length, ostial location, location on a bend, difficult access, and age, and was directly associated with greater Thrombolysis in Myocardial Infarction (TIMI) trial flow irate and more jeopardized myocardium. Predictors of PICA suitability for 99% to 100% lesions were a lower American College of Cardiology/American Heart Association class and higher TIMI grade. Predictors for 50% to 95% stenoses were more jeopardized myocardium, larger reference diameter, and more proximal vessel location, and for 99% to 100% occlusions, more jeopardized myocardium and shorter duration of occlusion. Suitability for PTCA depended on lesion patency (<99%) and multiple morphologic characteristics that contrasted with the few angiographic features that adversely affect CABG suitability.

Original languageEnglish (US)
Pages (from-to)805-814
Number of pages10
JournalAmerican Journal of Cardiology
Volume77
Issue number10
DOIs
StatePublished - Apr 15 1996
Externally publishedYes

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Coronary Balloon Angioplasty
Angioplasty
Coronary Artery Bypass
Myocardium
Pathologic Constriction
Myocardial Infarction
Multivariate Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Angiographic correlates of lesion relevance and suitability for percutaneous transluminal coronary angioplasty and coronary artery bypass grafting in the Bypass Angioplasty Revascularization Investigation study (BARI). / Botas, Javier; Stadius, Michael L.; Bourassa, Martial G.; Rosen, Allan D.; Schaff, Hartzell V; Sopko, George; Williams, David O.; McMillan, Alex; Alderman, Edwin L.

In: American Journal of Cardiology, Vol. 77, No. 10, 15.04.1996, p. 805-814.

Research output: Contribution to journalArticle

Botas, Javier ; Stadius, Michael L. ; Bourassa, Martial G. ; Rosen, Allan D. ; Schaff, Hartzell V ; Sopko, George ; Williams, David O. ; McMillan, Alex ; Alderman, Edwin L. / Angiographic correlates of lesion relevance and suitability for percutaneous transluminal coronary angioplasty and coronary artery bypass grafting in the Bypass Angioplasty Revascularization Investigation study (BARI). In: American Journal of Cardiology. 1996 ; Vol. 77, No. 10. pp. 805-814.
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abstract = "The Bypass Angioplasty Revascularization Investigation (BARI) randomized 1,829 patients to percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass grafting (CABG). Clinical site angiographers categorized lesions of ≥50{\%} diameter stenosis (n = 4,977) as clinically significant (86.4{\%}) or nonsignificant (13.6{\%}), and as favorable or nonfavorable for PTCA or CABG. More lesions were considered favorable for revascularization by CABG than by PTCA (91.5{\%} vs 78.4{\%}; p <0.001), particularly in the subgroup of 99{\%} to 100{\%} lesions (77.6{\%} for CABG vs 21.9{\%} for PTCA; p <0.001). Lesion features, characterized by the BARI core laboratory, were correlated with clinical site angiographers' assessment of clinical importance and suitability for PTCA or CABG. By multivariate analysis, positive predictors of clinical importance for 50{\%} to 95{\%} stenoses were greater stenosis severity, more jeopardized myocardium, larger reference diameter, and proximal vessel location. For 99{\%} to 100{\%} occlusions, predictors were shorter duration of occlusion and more jeopardized myocardium. PTCA suitability for 50{\%} to 95{\%} stenoses was inversely related to lesion length, ostial location, location on a bend, difficult access, and age, and was directly associated with greater Thrombolysis in Myocardial Infarction (TIMI) trial flow irate and more jeopardized myocardium. Predictors of PICA suitability for 99{\%} to 100{\%} lesions were a lower American College of Cardiology/American Heart Association class and higher TIMI grade. Predictors for 50{\%} to 95{\%} stenoses were more jeopardized myocardium, larger reference diameter, and more proximal vessel location, and for 99{\%} to 100{\%} occlusions, more jeopardized myocardium and shorter duration of occlusion. Suitability for PTCA depended on lesion patency (<99{\%}) and multiple morphologic characteristics that contrasted with the few angiographic features that adversely affect CABG suitability.",
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AU - Bourassa, Martial G.

AU - Rosen, Allan D.

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