Angiogenesis in the kidney: A new therapeutic target?

Lilach O. Lerman, Alejandro R. Chade

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Purpose of review The prevalence of chronic kidney disease has been growing consistently for the past decades. Renal failure is often associated with defective angiogenesis, and recognition of the contribution of the renal microcirculation to the progression of chronic renal disease may aid in the development of therapeutic interventions. Recent findings Intra-renal proliferation, remodeling, and/or rarefaction of microvessels in response to injury can all aggravate nephron damage, and experimental evidence suggests that they may constitute the early steps in the complex pathways involved in progressive renal injury. Recent studies showed the benefits of targeted interventions deemed to promote neovascularization (e.g. progenitor cells, growth factors) on the ischemic myocardium and brain and in a few models of renal disease. Summary Evidence of aberrant renal microvascular architecture in various forms of renal disease provides the impetus to attempt modulating the renal microcirculation to interfere with the disease process. Targeted interventions to preserve the renal microcirculation may not only decrease the evolving injury in renal vascular disease but also potentially constitute a coadjuvant intervention to become part of a comprehensive management plan to improve the success of parallel strategies to preserve renal function, such as revascularization.

Original languageEnglish (US)
Pages (from-to)160-165
Number of pages6
JournalCurrent opinion in nephrology and hypertension
Volume18
Issue number2
DOIs
StatePublished - Mar 2009

Keywords

  • Angiogenesis
  • Kidney
  • Microcirculation
  • Vascular rarefaction

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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