Angioedema: Classification, management and emerging therapies for the perioperative physician

Lopa Misra, Narjeet Khurmi, Terrence L. Trentman

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Angioedema is a rare condition which manifests as sudden localised, non‑pitting swelling of certain body parts including skin and mucous membranes. It is vital that anaesthesiologists understand this condition, as it may present suddenly in the perioperative period with airway compromise. To identify literature for this review, the authors searched the PubMed, Medline, Embase, Scopus and Web of Science databases for English language articles covering a 10‑year period, 2006 through 2016. Angioedema can be either mast‑cell mediated or bradykinin‑induced. Older therapies for histaminergic symptoms are well known to anaesthesiologists (e.g., adrenaline, anti‑histamines and steroids), whereas older therapies for bradykinin‑induced symptoms include plasma and attenuated androgens. New classes of drugs for bradykinin‑induced symptoms are now available, including anti‑bradykinin, plasma kallikrein inhibitor and C1 esterase inhibitors. These can be used prophylactically or as rescue medications. Anaesthesiologists are in a unique position to coordinate perioperative care for this complex group of patients.

Original languageEnglish (US)
Pages (from-to)534-541
Number of pages8
JournalIndian Journal of Anaesthesia
Volume60
Issue number8
DOIs
StatePublished - Aug 2016

Keywords

  • Airway
  • Angioedema
  • Bradykinin
  • C1 esterase inhibitor
  • Histamine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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