Aneuploidy in health, disease, and aging

Robin M. Ricke, Jan M. Van Deursen

Research output: Contribution to journalReview article

77 Scopus citations

Abstract

Aneuploidy, an aberrant number of chromosomes, has been recognized as a feature of human malignancies for over a century, but compelling evidence for causality was largely lacking until mouse models for chromosome number instability were used. These in vivo studies have not only uncovered important new insights into the extremely complex aneuploidy-cancer relationship but also into the molecular mechanisms underlying proper and aberrant chromosome segregation. A series of diverse mouse models for the mitotic checkpoint protein BubR1 has provided evidence for a provocative novel link between aneuploidization and the development of age-related pathologies.

Original languageEnglish (US)
Pages (from-to)11-21
Number of pages11
JournalJournal of Cell Biology
Volume201
Issue number1
DOIs
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Cell Biology

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