Anesthesia outcomes in a randomized double-blind trial of sevoflurane and thiopental for induction of general anesthesia in electroconvulsive therapy

Keith G. Rasmussen, Daniel R. Laurila, Bret M. Brady, Christy L. Lewis, Kimberly D. Niemeyer, Norazlina M. Sun, Marie E.S. Marienau, W. Michael Hooten, Darrell R. Schroeder, Thomas M. Spackman

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The purpose of the study was to compare hemodynamics and postanesthetic tolerability of sevoflurane versus thiopental in electroconvulsive therapy (ECT). The design was a randomized double-blind trial in the ECT suite of a tertiary referral medical center. Thirty-one patients were randomized to either sevoflurane or thiopental induction of anesthesia for up to 6 of each subject's ECT treatments. Measurements included hemodynamics (heart rate and blood pressure), arrhythmias, posttreatment orientation, time to first breath, and posttreatment side effects. Sevoflurane compared favorably with thiopental in terms of hemodynamics and time to first breath, although there was a slightly nonsignificant trend toward faster recovery with sevoflurane. Sevoflurane was associated with significantly better postictal orientation 20 minutes after the treatment. We conclude that inhalational anesthesia with sevoflurane presents a well-tolerated alternative for ECT anesthesia.

Original languageEnglish (US)
Pages (from-to)236-238
Number of pages3
JournalJournal of ECT
Volume23
Issue number4
DOIs
StatePublished - Dec 1 2007

Keywords

  • Anesthesia
  • Electroconvulsive therapy
  • Sevoflurane
  • Thiopental

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Psychiatry and Mental health

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    Rasmussen, K. G., Laurila, D. R., Brady, B. M., Lewis, C. L., Niemeyer, K. D., Sun, N. M., Marienau, M. E. S., Hooten, W. M., Schroeder, D. R., & Spackman, T. M. (2007). Anesthesia outcomes in a randomized double-blind trial of sevoflurane and thiopental for induction of general anesthesia in electroconvulsive therapy. Journal of ECT, 23(4), 236-238. https://doi.org/10.1097/yct.0b013e318136e1b4