Anesthesia inhibits interferon-induced natural killer cell cytotoxicity via induction of CD8+ suppressor cells

Svetomir N. Markovic; Donna M. Murasko

doi:10.1006/cimm.1993.1256

Anesthesia inhibits interferon-induced natural killer cell cytotoxicity via induction of CD8⁺ suppressor cells

Svetomir N. Markovic, Donna M. Murasko

Hematology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Anesthesia (Avertin, halothane, isoflorane, ether, or ketamine/xylazan) of mice inhibits subsequent stimulation of splenic natural killer cell (NK) cytotoxicity by interferon (IFN) treatment either in vitro and in vivo. The current data demonstrate (a) in vitro depletion of CD8⁺ cells from mononuclear splenocytes of anesthetized mice restored the ability of NK cells to respond in vitro to IFN stimulation and (b) coincubation of CD8⁺ splenocytes from anesthetized mice with CD8^- splenocytes of naive mice resulted in a significant reduction of the IFN-induced stimulation of NK activity in the coculture. These results suggest that anesthesia induces CD8+ cells that suppress stimulation of NK cytotoxicity by IFN.

Original language	English (US)
Pages (from-to)	474-480
Number of pages	7
Journal	Cellular Immunology
Volume	151
Issue number	2
DOIs	https://doi.org/10.1006/cimm.1993.1256
State	Published - Oct 15 1993

ASJC Scopus subject areas

Immunology

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10.1006/cimm.1993.1256

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title = "Anesthesia inhibits interferon-induced natural killer cell cytotoxicity via induction of CD8+ suppressor cells",

abstract = "Anesthesia (Avertin, halothane, isoflorane, ether, or ketamine/xylazan) of mice inhibits subsequent stimulation of splenic natural killer cell (NK) cytotoxicity by interferon (IFN) treatment either in vitro and in vivo. The current data demonstrate (a) in vitro depletion of CD8+ cells from mononuclear splenocytes of anesthetized mice restored the ability of NK cells to respond in vitro to IFN stimulation and (b) coincubation of CD8+ splenocytes from anesthetized mice with CD8- splenocytes of naive mice resulted in a significant reduction of the IFN-induced stimulation of NK activity in the coculture. These results suggest that anesthesia induces CD8+ cells that suppress stimulation of NK cytotoxicity by IFN.",

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AB - Anesthesia (Avertin, halothane, isoflorane, ether, or ketamine/xylazan) of mice inhibits subsequent stimulation of splenic natural killer cell (NK) cytotoxicity by interferon (IFN) treatment either in vitro and in vivo. The current data demonstrate (a) in vitro depletion of CD8+ cells from mononuclear splenocytes of anesthetized mice restored the ability of NK cells to respond in vitro to IFN stimulation and (b) coincubation of CD8+ splenocytes from anesthetized mice with CD8- splenocytes of naive mice resulted in a significant reduction of the IFN-induced stimulation of NK activity in the coculture. These results suggest that anesthesia induces CD8+ cells that suppress stimulation of NK cytotoxicity by IFN.

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Anesthesia inhibits interferon-induced natural killer cell cytotoxicity via induction of CD8⁺ suppressor cells

Abstract

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