Anemia or low hemoglobin levels preceding Parkinson disease: A case-control study

Rodolfo Savica, B. R. Grossardt, J. M. Carlin, M. Icen, James Howard Bower, J. E. Ahlskog, D. M. Maraganore, D. P. Steensma, Walter A Rocca

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

OBJECTIVE: It has been suggested that anemia may be a risk factor for dementia, for restless legs syndrome, and for Parkinson disease (PD). Thus, we investigated the association of anemia with the subsequent risk of PD using a case-control study design. METHODS: We used the medical records-linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995. Each incident case was matched by age (±1 year) and sex to a general population control. We reviewed the complete medical records of cases and controls in the system to detect anemia defined using the World Health Organization criteria. RESULTS: Anemia was more common in the history of cases than of controls (odds ratio 2.00, 95% confidence interval 1.31-3.06, p = 0.001). The association remained significant after adjustment for cigarette smoking, exposure to pesticides, or hysterectomy (in women). The association was not significantly different between men and women, or between PD patients with or without rest tremor. Analyses stratified by time of onset of anemia showed a greater association for anemia that started 20 to 29 years before the onset of PD. Hemoglobin levels were slightly but consistently lower in cases than in controls across all ages. CONCLUSIONS: Our results support an association between anemia experienced early in life and the later development of Parkinson disease. The interpretation of this association remains uncertain.

Original languageEnglish (US)
Pages (from-to)1381-1387
Number of pages7
JournalNeurology
Volume73
Issue number17
DOIs
StatePublished - Oct 2009
Externally publishedYes

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Parkinson Disease
Case-Control Studies
Anemia
Hemoglobins
Medical Record Linkage
Restless Legs Syndrome
Population Control
Tremor
Hysterectomy
Pesticides
Medical Records
Dementia
Epidemiology
Smoking
History
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Anemia or low hemoglobin levels preceding Parkinson disease : A case-control study. / Savica, Rodolfo; Grossardt, B. R.; Carlin, J. M.; Icen, M.; Bower, James Howard; Ahlskog, J. E.; Maraganore, D. M.; Steensma, D. P.; Rocca, Walter A.

In: Neurology, Vol. 73, No. 17, 10.2009, p. 1381-1387.

Research output: Contribution to journalArticle

Savica, R, Grossardt, BR, Carlin, JM, Icen, M, Bower, JH, Ahlskog, JE, Maraganore, DM, Steensma, DP & Rocca, WA 2009, 'Anemia or low hemoglobin levels preceding Parkinson disease: A case-control study', Neurology, vol. 73, no. 17, pp. 1381-1387. https://doi.org/10.1212/WNL.0b013e3181bd80c1
Savica, Rodolfo ; Grossardt, B. R. ; Carlin, J. M. ; Icen, M. ; Bower, James Howard ; Ahlskog, J. E. ; Maraganore, D. M. ; Steensma, D. P. ; Rocca, Walter A. / Anemia or low hemoglobin levels preceding Parkinson disease : A case-control study. In: Neurology. 2009 ; Vol. 73, No. 17. pp. 1381-1387.
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