Androgens and prostate cancer: Are the descriptors valid?

Pradip Roy-Burman, Donald J. Tindall, Diane M. Robins, Norman M. Greenberg, Mary J.C. Hendrix, Suresh Mohla, Robert H. Getzenberg, John T. Isaacs, Kenneth J. Pienta

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The term androgen-independent cancer has now become a misnomer. Given that the androgen receptor can be activated by even low androgen concentrations or via protein modifications or other protein-protein interactions, a growing prostate cancer has the chance of assuming an androgen depletion-independent state, without necessarily bypassing the androgen signaling processes. It is thus suggested that "androgen-independent (Al)" cancer should be more accurately termed "androgen depletion-independent (ADI)" cancer.

Original languageEnglish (US)
Pages (from-to)4-5
Number of pages2
JournalCancer Biology and Therapy
Volume4
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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  • Cite this

    Roy-Burman, P., Tindall, D. J., Robins, D. M., Greenberg, N. M., Hendrix, M. J. C., Mohla, S., Getzenberg, R. H., Isaacs, J. T., & Pienta, K. J. (2005). Androgens and prostate cancer: Are the descriptors valid? Cancer Biology and Therapy, 4(1), 4-5. https://doi.org/10.4161/cbt.4.1.1563