Androgen stimulation and laryngeal development

N. S. Beckford, D. Schaid, S. R. Rood, B. Schanbacher

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Androgen-induced changes in laryngeal growth patterns were studied using a sheep animal model. Forty-eight lambs were divided into eight treatment groups. Lambs in seven of the groups were castrated at birth, while lambs in the eight group served as an intact (non-castrated) control. Six groups were then treated with varying doses of testosterone and dihydrotestosterone, while the seventh served as a castrated, nontreated control. All animals were killed and gross dissections of the larynges were performed. Thirty-four linear and angular measurements were obtained from each larynx. The mean superior thyroid horn separation showed the most dramatic androgen-induced effect (p=0.023). Laryngeal anterior-posterior diameter, superior thyroid horn height, posterior thyroid cartilage width, thyroid cartilage angle, and vocal process to arytenoid base distances all demonstrated positive dose-response relationships. Hypoandrogenic levels appeared to have an inhibitory effect upon laryngeal growth when compared to castrated controls.

Original languageEnglish (US)
Pages (from-to)634-640
Number of pages7
JournalAnnals of Otology, Rhinology and Laryngology
Volume94
Issue number6 I
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Otorhinolaryngology

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